ID   A0A2K6DG31_MACNE        Unreviewed;       575 AA.
AC   A0A2K6DG31;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=EBF transcription factor 2 {ECO:0000313|Ensembl:ENSMNEP00000034887.1};
GN   Name=EBF2 {ECO:0000313|Ensembl:ENSMNEP00000034887.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000034887.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000034887.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU004489}.
CC   -!- SIMILARITY: Belongs to the COE family. {ECO:0000256|ARBA:ARBA00010340,
CC       ECO:0000256|RuleBase:RU004489}.
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DR   RefSeq; XP_011740201.1; XM_011741899.1.
DR   AlphaFoldDB; A0A2K6DG31; -.
DR   SMR; A0A2K6DG31; -.
DR   STRING; 9545.ENSMNEP00000034887; -.
DR   Ensembl; ENSMNET00000059339.1; ENSMNEP00000034887.1; ENSMNEG00000040606.1.
DR   GeneID; 105482039; -.
DR   KEGG; mni:105482039; -.
DR   CTD; 64641; -.
DR   GeneTree; ENSGT00950000182859; -.
DR   OMA; QGYMRNS; -.
DR   OrthoDB; 3641706at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000040606; Expressed in heart and 2 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0060612; P:adipose tissue development; IEA:Ensembl.
DR   GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR   GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
DR   GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR   CDD; cd11606; COE_DBD; 1.
DR   CDD; cd01175; IPT_COE; 1.
DR   Gene3D; 1.10.287.4280; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.60.40.3180; Transcription factor COE1, DNA-binding domain; 1.
DR   InterPro; IPR032200; COE_DBD.
DR   InterPro; IPR038173; COE_DBD_sf.
DR   InterPro; IPR032201; COE_HLH.
DR   InterPro; IPR038006; COE_IPT.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR003523; Transcription_factor_COE.
DR   InterPro; IPR018350; Transcription_factor_COE_CS.
DR   PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR   PANTHER; PTHR10747:SF33; TRANSCRIPTION FACTOR COE2; 1.
DR   Pfam; PF16422; COE1_DBD; 1.
DR   Pfam; PF16423; COE1_HLH; 1.
DR   Pfam; PF01833; TIG; 1.
DR   SMART; SM00429; IPT; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   PROSITE; PS01345; COE; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|RuleBase:RU004489};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004489};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004489};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004489};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004489};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004489};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004489};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004489}.
FT   DOMAIN          252..336
FT                   /note="IPT/TIG"
FT                   /evidence="ECO:0000259|SMART:SM00429"
FT   REGION          441..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   575 AA;  62620 MW;  F0FCDF677B354239 CRC64;
     MFGIQDTLGR GPALKEKSLG AEMDSVRSWV RNVGVVDANV AAQSGVALSR AHFEKQPPSN
     LRKSNFFHFV LALYDRQGQP VEIERTAFVD FVENDKEQGN EKTNNGTHYK LQLLYSNGVR
     TEQDLYVRLI DSVTKQPIAY EGQNKNPEMC RVLLTHEVMC SRCCEKKSCG NRNETPSDPV
     IIDRFFLKFF LKCNQNCLKT AGNPRDMRRF QVVLSTTVNV DGHVLAVSDN MFVHNNSKHG
     RRARRLDPSE ATPCIKAISP SEGWTTGGAM VIIIGDNFFD GLQVVFGTML VWSELITPHA
     IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFIYTALNE PTIDYGFQRL QKVIPRHPGD
     PERLAKEMLL KRAADLVEAL YGTPHNNQDI ILKRAADIAE ALYSVPRNPS QLPALSSSPA
     HSGMMGINSY GSQLGVSISE STQGNNQGYI RNTSSISPRG YSSSSTPQQS NYSTSSNSMN
     GYSNVPMANL GVPGSPGFLN GSPTGSPYGI MSSSPTVGSS STSSILPFSS SVFPAVKQKS
     AFAPVIRPQG SPSPACSSGN GNGFRAMTGL VVPPM
//