ID   A0A2K6DHP7_MACNE        Unreviewed;       459 AA.
AC   A0A2K6DHP7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=tRNA (guanine(10)-N2)-methyltransferase homolog {ECO:0000256|ARBA:ARBA00013960};
DE   AltName: Full=tRNA guanosine-2'-O-methyltransferase TRM11 homolog {ECO:0000256|ARBA:ARBA00032604};
GN   Name=TRMT11 {ECO:0000313|Ensembl:ENSMNEP00000035421.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000035421.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000035421.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC       tRNA methyltransferase complex that mediates the methylation of the
CC       guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC       {ECO:0000256|ARBA:ARBA00002425}.
CC   -!- SUBUNIT: Interacts with TRMT112. {ECO:0000256|ARBA:ARBA00033754}.
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DR   AlphaFoldDB; A0A2K6DHP7; -.
DR   Ensembl; ENSMNET00000059878.1; ENSMNEP00000035421.1; ENSMNEG00000040840.1.
DR   GeneTree; ENSGT00390000018131; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000040840; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR000241; RlmKL-like_Mtase.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR   PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR   PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR   Pfam; PF01170; UPF0020; 1.
DR   PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
DR   PROSITE; PS51627; SAM_MT_TRM11; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT   DOMAIN          190..321
FT                   /note="UPF0020"
FT                   /evidence="ECO:0000259|Pfam:PF01170"
SQ   SEQUENCE   459 AA;  52952 MW;  A5CA153EA795CE4E CRC64;
     MAPSCTLNRY LLLMAQEHLE FRLPEIKSLL SLFGGQFASS QETYGKSPFW ILSIPSEDIA
     RNLMKRTVCA KSIFELWGHG QSPEELYSSL KNYPVEKMVP FLHSDSTYKI KIHTFNKTLT
     QEEKIKRIDA LEFLPFEGKV NLKKPQHVFS VLEDYGLDPN RIPENPHNIY FGRWIADGQR
     ELIESYSVKK RHFIGNTSMD AGLSFIMANH GKVKENDIVF DPFVGTGGLL IASAHFGAYV
     YGTDIDYNTV HGLGKATRKN QKWRGPDENI RANLRQYGLE KYYLDVLVSD ASKPSWRKGT
     YFDAIITDPP YGIRESTRRT EEACSFPDNL AFLKIHVPVS LSYHLSDMFL DLLNFAAETL
     VLGGRLVYWL PVYTPEYTEE MVPWHPCLKL ISNCEQKLSS HTSRRLITME KVQKFENRDQ
     YSHLLSDHFL PYQGHNSFRE KYFSGVTKRI AKEEKSTQE
//