ID   A0A2K6DIF2_MACNE        Unreviewed;       957 AA.
AC   A0A2K6DIF2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Sorting nexin 13 {ECO:0000313|Ensembl:ENSMNEP00000035694.1};
GN   Name=SNX13 {ECO:0000313|Ensembl:ENSMNEP00000035694.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000035694.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000035694.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   RefSeq; XP_011729366.1; XM_011731064.1.
DR   AlphaFoldDB; A0A2K6DIF2; -.
DR   SMR; A0A2K6DIF2; -.
DR   STRING; 9545.ENSMNEP00000035694; -.
DR   Ensembl; ENSMNET00000060153.1; ENSMNEP00000035694.1; ENSMNEG00000040568.1.
DR   GeneID; 105475640; -.
DR   KEGG; mni:105475640; -.
DR   CTD; 23161; -.
DR   GeneTree; ENSGT00950000182856; -.
DR   OrthoDB; 5392990at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000040568; Expressed in colon and 12 other cell types or tissues.
DR   GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR   CDD; cd06873; PX_SNX13; 1.
DR   CDD; cd08719; RGS_SNX13; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   InterPro; IPR003114; Phox_assoc.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR037437; SNX13_PX.
DR   InterPro; IPR037896; SNX13_RGS.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF02194; PXA; 1.
DR   Pfam; PF00615; RGS; 1.
DR   SMART; SM00312; PX; 1.
DR   SMART; SM00313; PXA; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS51207; PXA; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        30..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          97..284
FT                   /note="PXA"
FT                   /evidence="ECO:0000259|PROSITE:PS51207"
FT   DOMAIN          373..496
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   DOMAIN          559..680
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
SQ   SEQUENCE   957 AA;  111024 MW;  6D9ABE091D4FD159 CRC64;
     MLTETSLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF GKTNSEKYLE
     QCEHSFLPPT STGVPKCLEE MKREARTIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY
     YTLSDDESFL LEIRQTLQNA LIQFATRSKE IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT
     EKDDQVKGTA EDLVDTFFEV EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD
     FQNKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI
     GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR LQSGKEINTV
     KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL
     LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL SEKASPRVTV DDYLVAKLAD TLNHEDPTPE
     IFDDIQRKVY ELMLRDERFY PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT
     GSINLSLDDL SNVSSDDSVQ LHAYISDTGV CNDHGKTYAL YAITVHRRNL NSEEMWKTYR
     RYSDFHDFHM RITEQFESLS SILKLPGKKT FNNMDRDFLE KRKKDLNAYL QLLLAPEMMK
     ASPALAHYVY DFLENKAYSK GKGDFARKMD TFVNPLRNSM RNVSNAVKSL PDSLAEGMTK
     MSDNMGKMSE RLGQDIKQSF FKVPPLIPKT DSDPEHRRVS AQLDDNVDDN IPLRVMLLLM
     DEVFDLKERN QWLRRNIKNL LQQLIRATYG DTINRKIVDH VDWMTSPEQV ADSVKRFRDA
     FWPNGILAET VPCRDKSIRM RTRVAGKTKL LAIMPDELKH IIGAETTRKG ILRVFEMFQH
     NQLNRRMVYV FLEGFLETLF PQYKFRELFN KLHSRSKQMQ KYKQKLQTTQ APSLQKR
//