ID A0A2K6DIF4_MACNE Unreviewed; 171 AA.
AC A0A2K6DIF4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Protein phosphatase 1 regulatory subunit 1B {ECO:0000256|ARBA:ARBA00020090};
DE AltName: Full=DARPP-32 {ECO:0000256|ARBA:ARBA00029874};
DE AltName: Full=Dopamine- and cAMP-regulated neuronal phosphoprotein {ECO:0000256|ARBA:ARBA00030254};
GN Name=PPP1R1B {ECO:0000313|Ensembl:ENSMNEP00000035695.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000035695.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000035695.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Inhibitor of protein-phosphatase 1.
CC {ECO:0000256|ARBA:ARBA00002900}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the protein phosphatase inhibitor 1 family.
CC {ECO:0000256|ARBA:ARBA00007775}.
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DR RefSeq; XP_011723618.1; XM_011725316.1.
DR AlphaFoldDB; A0A2K6DIF4; -.
DR Ensembl; ENSMNET00000060154.1; ENSMNEP00000035695.1; ENSMNEG00000041007.1.
DR GeneID; 105472249; -.
DR KEGG; mni:105472249; -.
DR CTD; 84152; -.
DR GeneTree; ENSGT00730000111283; -.
DR OrthoDB; 4018581at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000041007; Expressed in temporal lobe and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR008466; PPP1R1A/B/C.
DR PANTHER; PTHR15417:SF2; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B; 1.
DR PANTHER; PTHR15417; PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN; 1.
DR Pfam; PF05395; DARPP-32; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..105
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 171 AA; 19381 MW; 6874C2A54F3A4FFD CRC64;
MDPKDRKKIQ FSVPAPPSQL DPRQVEMIRR RRPTPAMLFR LSEHSSPAVQ RIAESHLQSI
SNLNENQASE EEDELGELRE LGYPREEDEE EEEDDEEEEE EEDSQAEVLK VIRQSAGQKT
TCGQGLEGPW ERPPPLDEPE RDGSSEDQVE DPALSEPGEE PQRPSPSEPG T
//
