ID A0A2K6DJY2_MACNE Unreviewed; 451 AA.
AC A0A2K6DJY2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=ETS variant transcription factor 6 {ECO:0000313|Ensembl:ENSMNEP00000036208.1};
GN Name=ETV6 {ECO:0000313|Ensembl:ENSMNEP00000036208.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000036208.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000036208.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K6DJY2; -.
DR Ensembl; ENSMNET00000060671.1; ENSMNEP00000036208.1; ENSMNEG00000041224.1.
DR GeneTree; ENSGT00940000159508; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000041224; Expressed in thymus and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08535; SAM_PNT-Tel_Yan; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF19; TRANSCRIPTION FACTOR ETV6; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 39..123
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 338..419
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 451 AA; 52793 MW; 04A4CA446E483732 CRC64;
GDGVPKKCSP QERISYTPPE SPVPSYASST PLHVPVPRAL RMEEDSIRLP AHLRLQPIYW
SRDDVAQWLK WAENEFSLRP IDSNTFEMNG KALLLLTKED FRYRSPHSGD VLYELLQHIL
KQRKPRILFS PFFHPGNSIH TQPEVILHQN HEEDNCVQRT PRPSVDNVHH NPPTIELLHR
SRSPITTNHR PSPDPEQRPL RSPLDNMIRR LSPAERAQGP RPHQENNHQE SYPLSVSPME
NNHCPASSES HPKPSSPRQE STRVIQLMPS PIMHPLILNP RHSVDFKQSR LSEDGLHREG
KPINLSHRED LAYMNHIMVS VSPPEEHAMP IGRIADCRLL WDYVYQLLSD SRYENFIRWE
DKESKIFRIV DPNGLARLWG NHKNRTNMTY EKMSRALRHY YKLNIIRKEP GQRLLFRFMK
TPDEIMSGRT DRLEHLESQE LDEQIYQEDE C
//
