ID A0A2K6DLA1_MACNE Unreviewed; 454 AA.
AC A0A2K6DLA1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=TEA domain transcription factor 4 {ECO:0000313|Ensembl:ENSMNEP00000036715.1};
GN Name=TEAD4 {ECO:0000313|Ensembl:ENSMNEP00000036715.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000036715.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000036715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR002603}.
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DR AlphaFoldDB; A0A2K6DLA1; -.
DR STRING; 9545.ENSMNEP00000036715; -.
DR Ensembl; ENSMNET00000061181.1; ENSMNEP00000036715.1; ENSMNEG00000041421.1.
DR GeneTree; ENSGT00950000182956; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000041421; Expressed in skeletal muscle tissue and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0035329; P:hippo signaling; IEA:Ensembl.
DR GO; GO:1902459; P:positive regulation of stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0001830; P:trophectodermal cell fate commitment; IEA:Ensembl.
DR Gene3D; 2.70.50.80; -; 1.
DR Gene3D; 6.10.20.40; TEA/ATTS domain; 1.
DR InterPro; IPR000818; TEA/ATTS_dom.
DR InterPro; IPR038096; TEA/ATTS_sf.
DR InterPro; IPR016361; TEF_metazoa.
DR InterPro; IPR041086; YBD.
DR PANTHER; PTHR11834; TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED; 1.
DR PANTHER; PTHR11834:SF2; TRANSCRIPTIONAL ENHANCER FACTOR TEF-3; 1.
DR Pfam; PF01285; TEA; 1.
DR Pfam; PF17725; YBD; 1.
DR PIRSF; PIRSF002603; TEF; 1.
DR PRINTS; PR00065; TEADOMAIN.
DR SMART; SM00426; TEA; 1.
DR PROSITE; PS00554; TEA_1; 1.
DR PROSITE; PS51088; TEA_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR002603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR002603};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR002603};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR002603}.
FT DOMAIN 64..140
FT /note="TEA"
FT /evidence="ECO:0000259|PROSITE:PS51088"
FT DNA_BIND 64..140
FT /note="TEA"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00505"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..233
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 50499 MW; 9B37A234F3F439B0 CRC64;
MTHTVRPLLT GAAVPVPTGP TGAPPSGALE GKAGTITSNE WSSPNSPEGS NVSGGSQALD
KPIDNDAEGV WSPDIEQSFQ EALAIYPPCG RRKIILSDEG KMYGRNELIA RYIKLRTGKT
RTRKQVSSHI QVLARRKARE IQAKLKDQAA KDKALQSMAA MSSAQIISAT AFHSSMALAR
GPSRPAVSGC RDPWWHVKPF SQQTYAVQPP LPLPGFESPA GPAPSPSAPP APPWQGRSVA
SSKLWMLEFS AFLEQQQDPD TYNKHLFVHI GQSSPSYSDP YLEAVDIRQI YDKFPEKKGG
LKELFERGPS NAFFLVKFWA DLNTNIEDEG SSFYGVSSQY ESPENMIITC STKVCSFGKQ
VVEKVETEYA RYENGHYSYR IHRSPLCEYM INFIHKLKHL PEKYMMNSVL ENFTILQVVT
NRDTQETLLC IAYVFEVSAS EHGAQHHIYR LVKE
//
