ID A0A2K6DMB1_MACNE Unreviewed; 774 AA.
AC A0A2K6DMB1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN Name=SLC9A5 {ECO:0000313|Ensembl:ENSMNEP00000037038.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000037038.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000037038.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Endosome
CC membrane {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC ECO:0000256|RuleBase:RU003722}.
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DR AlphaFoldDB; A0A2K6DMB1; -.
DR Ensembl; ENSMNET00000061504.1; ENSMNEP00000037038.1; ENSMNEG00000041562.1.
DR GeneTree; ENSGT00940000159190; -.
DR OMA; AMHHLLC; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000041562; Expressed in spleen and 2 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR018410; Na/H_exchanger_3/5.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF56; SODIUM_HYDROGEN EXCHANGER 5; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01087; NAHEXCHNGR3.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..333
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 534..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..595
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..741
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 85740 MW; 8AC253E5A1A21A6C CRC64;
MPSRLFFDNL GAILTYAVVG TLWNAFTTGA ALWGLQQAGL VAPRVQAGLL DFLLFGSLIS
AVDPVAVLAV FEEVHVNETL FIIVFGESLL NDAVTVVLYK VCNSFVEMGS ANVQATDYLK
GVASLFVVSL GGAAVGLVFA FLLALTTRFT KRVRIIEPLL VFLLAYAAYL TAEMASLSAI
LAVTMCGLGC KKYVEANISH KSRTTVKYTM KTLASCAETV IFMLLGISAV DSSKWAWDSG
LVLGTLIFIL FFRALGVVLQ TWVLNQFRLV PLDKIDQVVM SYGGLRGAVA FALVILLDRT
KVPAKDYFVA TTIVVVFFTV IVQGLTIKPL VKWLKVKRSE HHKPTLNQEL HEHTFDHILA
AVEDVVGHHG YHYWRDRWEQ FDKKYLSQLL MRRSAYRIRD QIWDVYYRLN IRDAISFVDQ
GGHVLSSTGL TLPSMPSRNS VAETSVTNLL RESGSGACLD LQVIDTVRSG RDREDAVMHH
LLCGGLYKPR RRYKASCSRH FISEDAQERQ DKEVFQQNMK RRLESFKSTK HNICFTKSKP
RPRKNGRRKK DGVANAEATN GKPRDLGFQD TAAVILTVES EEEDEESDSS ETEKEDDEGI
IFVARATSEV LQEGKVSGNL EVCPSPRIIP PSPTCAEKEL PWKSGQGDLA VYVSSETTKI
VPVDMQTGWN QSISSLESLA SPPCNQAPIL TCLPPHPRGA EEPQAPLHLP SDPRPSFAFP
PSLAKAGRSR SESSADLPQQ QELQPLMGHK DHTHLSPGTT TSHWCIQFNR GSRL
//
