ID A0A2K6DNL1_MACNE Unreviewed; 1698 AA.
AC A0A2K6DNL1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMNEP00000037498.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000037498.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000037498.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR Ensembl; ENSMNET00000061965.1; ENSMNEP00000037498.1; ENSMNEG00000041718.1.
DR GeneTree; ENSGT00940000155739; -.
DR OMA; DYMNSYD; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000041718; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR CDD; cd03584; NTR_complement_C4; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.1540; -; 2.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR001840; Anaphylatoxn_comp_syst_dom.
DR InterPro; IPR048847; C4_MG1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11412:SF86; COMPLEMENT C4-A-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21145; C4_MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF01759; NTR; 1.
DR Pfam; PF07678; TED_complement; 1.
DR PRINTS; PR00004; ANAPHYLATOXN.
DR SFLD; SFLDG01179; Complement_C3/C4_Like; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1698
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014419510"
FT DOMAIN 702..736
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 1549..1696
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
SQ SEQUENCE 1698 AA; 187658 MW; 2253C262B9062CE4 CRC64;
MRLLWGLIWA SSFFTLSLQK PRLLLFSPSV VHLGVPLSVG VQLQDVPRGQ VVKGSVFLRN
PSHNNVPCSP KVDFTLSSDR DFALLSLQVP LKDVKSCGLH QLLRGPEVQL VAQSPWLKDS
LSRKMNIQGV NLLFSSRRGH LFLQTDQPIY NPGQRVQYRV FALDQKMRPS TDAITVTVEN
SHGLRVRKKD VYLPSSIFQD DFVIPDISEP GTWKISARFS DGLESNRSTQ FEVKKYVLPN
FEVKITPGKP YILTVPGHLD EIQLDIQARY IYGKPVQGVA YVRFGLLDED GKKTFLRGLE
SQTKLVNGQS HISLSKAEFQ DALGKLNMGM TDLLGLRLYV AAAIIESPGG EMEEAELTSW
SFVSSPFSLD LSKTKRHLVP GAPFLLQALV REMSGSPASG IPVKVSATVS SPGSVPEVRD
IQQNTDGSGQ VSIPIIIPQT ISELQLSVSA GSPYPAIARL TVAAPPSGGP GFLSIERPDS
RPPRVGDTLN LNLRAVGSGA TFSHYYYMIL SRGQIVFMNR EPKRTVTSVS VFVDHHLAPS
FYFVAFYYHG DHPVANSLRV DVQAGACEGK LELSVDGAKE YRNGESVKLH LETDSPALVA
LGALDTALYA VGSKSHKPLN MGKVFEVMNS YDLGCGPGGG DSALQVFQAA GLAFSDGEQW
TFSRKRLGCP KEKTTRRKRN VNFQKAINEK LGQYASPTAK RCCQDGVTRL PMRRSCEQRA
ARVQQPDCRE PFLSCCQFAE SLRKKNRTRG QVGLQRALEI LQEEDLIDED DIPVRSFFPE
NWLWRVETVD RFQILTLWLP DSLTTWEIHG LSLSKTKGLC VAAPVQLRVF RDFHLHLRLP
MSVRRFEQLE LRPVLYNYLA RNLTVSVHVS PVEGLCLAGG GGLAQQVLVP AGSARPVAFS
VVPTAAAAVS LKVVARGSFD FPVGDAVSKV LQIEKEGAIH TEELVYELNP LDHRGRTLEI
PGNSDPNMIP DGDFNSYVRV TASDPLDTLG SEGALSPGGV ASLLKLPQGC GEQTMIYLAP
TLAASRYLDK TEQWSALPPE TKDHAVDLIQ KGYMRIQQFR KADGSYAAWL SRDSSTWLTA
FVLKVLSLAQ EQVGGSPEKL QETSKWLLSQ QQADGSFQDP CPVLDRNMQG GLVGSDETVA
LTAFVTIALH HGLAVFQDEG AEELKQRVEA SISKANSFLG EKASAGLLGA HAAAITAYAL
TLTKASGDLR GVAHNNLMAM AQETGDNLYW GSVTSSQNNA VSPTPAPRNP ADPMPQAPAL
WIETTAYALL HLLLHEGKAE MADQTAAWLT RQGSFQGGFR STQDTVIALD ALSAYWIASH
TTEERGLNVT LSSTGRSGFR SHALQLNNRQ IRGLEEELQF SLGSKINVKV GGNSKGTLKV
LRIYNVLDMK NTTCQDLQIE VTVKGHVEYT MEANEDYEDY EYDELPARDD PGVPLQPVTP
LQLFEGRRNR RRREAPKLTS LSDRYVSHFE TEGPHVLLYF DSVPTSRECV GFEAVQEVPV
GLVQPASAAL YDYYNPERRC SVFYGAPSKS RLLATLCSAE VCQCAEGKCP RQRRALERGL
QDEDGYRMKF ACYYPRVEYG FQVKVLREDS RAAFRLFETK ITQVLHFTKD VKATVNQTRN
FLVRASCRLR LEPGREYLIM GLDGATYDLE GHPQYLLDSN SWIEEMPSER QCRSTRQRAA
CAQLHDFLQE YGTQGCQV
//
