ID A0A2K6DNV7_MACNE Unreviewed; 1353 AA.
AC A0A2K6DNV7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Proteoglycan 4 {ECO:0000313|Ensembl:ENSMNEP00000037595.1};
GN Name=PRG4 {ECO:0000313|Ensembl:ENSMNEP00000037595.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000037595.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000037595.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9545.ENSMNEP00000037595; -.
DR Ensembl; ENSMNET00000062064.1; ENSMNEP00000037595.1; ENSMNEG00000041863.1.
DR GeneTree; ENSGT00530000063751; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000041863; Expressed in liver and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00094; HX; 1.
DR Gene3D; 4.10.410.20; -; 2.
DR Gene3D; 2.110.10.10; Hemopexin-like domain; 1.
DR InterPro; IPR000585; Hemopexin-like_dom.
DR InterPro; IPR036375; Hemopexin-like_dom_sf.
DR InterPro; IPR018487; Hemopexin-like_repeat.
DR InterPro; IPR018486; Hemopexin_CS.
DR InterPro; IPR020436; SMB_chordata.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR22917; HEMOPEXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22917:SF1; PROTEOGLYCAN 4; 1.
DR Pfam; PF00045; Hemopexin; 1.
DR Pfam; PF01033; Somatomedin_B; 2.
DR PRINTS; PR00022; SOMATOMEDINB.
DR SMART; SM00120; HX; 2.
DR SMART; SM00201; SO; 2.
DR SUPFAM; SSF50923; Hemopexin-like domain; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 2.
DR PROSITE; PS00024; HEMOPEXIN; 1.
DR PROSITE; PS51642; HEMOPEXIN_2; 1.
DR PROSITE; PS00524; SMB_1; 2.
DR PROSITE; PS50958; SMB_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1353
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457576"
FT DOMAIN 26..69
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 70..108
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REPEAT 1141..1188
FT /note="Hemopexin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01011"
FT REGION 111..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..160
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..441
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..545
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..705
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..749
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..798
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..992
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 999..1038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 146164 MW; D525B16C49F29C5C CRC64;
MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC QHYMECCPDF
KRVCTVELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY ESFCAEVHNP TSPPSAKKAP
PPSGASQTIK STTKRSPKPP NKKKTKKVVE SEEITEEHSV SENQESSSSS SSSSSSSTIR
KIKSSKNSAA NRELQKKLKG KDNKKNRTKK KPTPKPPVVD EAGSGLDNGD FKVTTTPATS
TTQHNKVTTS PKITTAKPKN PRPSLPPNSD TSKQTSLTTN KETTVETKEP TTTNKQTSTD
GKETTSAKET QSVEKTSAKD LAPTSKVPAK PTPKAETTTK GPALTTPKEP TPTTPKEPAS
TTPKEPAPTT TKSAPTTPKE PAPTTPKEPA PTTPKKPAPI APKEPSPTTT KKPAPTTPKE
PLPTTTKEPA PTTPKEPATT TPKEPAPTTT KEPAPTTPKE PSPTTPKELT PTTPKEPTPT
PPKEPAPTTP KEPAPTPPKE PAPTTTKKPA PTTPKEPGPT TPKEPAPTTT KKPAPTTPKE
PVPTTPKELT PTTTKKPAPT TPKELTPTTT KKPAPTTPKE EPVPTTPKEL TPTTTKKPAP
TTPKELTPTT TKKPAPTTPK ELTPTIPEEL VPTTPEELTP TTPEEPTPTT PEEPTPTTPE
EPTPTTPEEP APTTPKAPAP TTPKEPAPKT APTTPKEPAP TTPKGTAPTT PKGTAPTTPK
GTAPKTLKEN APTTPKGTAP TTLNEPALTT PKQPAPKKLA PTTTKEPTPT TSDKPAPTTP
KEPAPTTPKK PAPTTPETPP ATTSEASTPT TTMEPPTSHK SPDESTPELS AEPTPKVLEN
SSKKPSVPTT KTPAVTKSEM TTIAKDKITE RDIRTTPETT TVAPKMTKET ATTTEKTTES
KITTTATEVT STTTQDTTPF KITTFKTTTL APKVTTTTKT ITTTEIMNKP EETAKPKDRA
TNSKATTAKP QKPTKAPKKP TSTKKPKTTP RVRKPKTTPT PPKMTSTMPE LNPTSRVAEA
MLQTTTRPSQ TPNSKLFEVN PKNEDAGGAE GETPHMLPRP HVFTPIVIPG MDYSLRVPNQ
GIIINPMLSD ETDICNGRPV DGLTTLRNGT LVAFRGHYFW MLSPFSPPSP ARRITEVWGI
PSPIDTVFTR CNCEGKTFFF KDSQYWRFTN DIKDAGYPKP IVKGFGGLTG QIVAALSIAK
YKNRPESVYF FKRGGSIQQY IYKQEPVQKC PGRRPALNYP VYGETTQVRR RRFERAIGPS
LTHTIRIHYS PVRLAYQDKG FLHNEVKVST LWRGLPNVVT SAISLPNIRK PDGYDYYAFS
KDQYYNIDVP SRTARAITTR SGQTLSKVWY NCP
//
