ID   A0A2K6DNW2_MACNE        Unreviewed;       690 AA.
AC   A0A2K6DNW2;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Receptor tyrosine kinase like orphan receptor 2 {ECO:0000313|Ensembl:ENSMNEP00000037600.1};
GN   Name=ROR2 {ECO:0000313|Ensembl:ENSMNEP00000037600.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000037600.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000037600.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR   AlphaFoldDB; A0A2K6DNW2; -.
DR   Ensembl; ENSMNET00000062070.1; ENSMNEP00000037600.1; ENSMNEG00000041877.1.
DR   GeneTree; ENSGT00940000153947; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000041877; Expressed in colon.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd07468; CRD_TK_ROR2; 1.
DR   CDD; cd00108; KR; 1.
DR   CDD; cd05091; PTKc_Ror2; 1.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR020067; Frizzled_dom.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000001; Kringle.
DR   InterPro; IPR013806; Kringle-like.
DR   InterPro; IPR018056; Kringle_CS.
DR   InterPro; IPR038178; Kringle_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR016247; Tyr_kinase_rcpt_ROR.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   PANTHER; PTHR24416:SF132; TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2; 1.
DR   Pfam; PF01392; Fz; 1.
DR   Pfam; PF00051; Kringle; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PIRSF; PIRSF000624; TyrPK_TMrec_ROR; 1.
DR   PRINTS; PR00018; KRINGLE.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00130; KR; 1.
DR   SUPFAM; SSF57440; Kringle-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50038; FZ; 1.
DR   PROSITE; PS00021; KRINGLE_1; 1.
DR   PROSITE; PS50070; KRINGLE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRSR:PIRSR000624-
KW   2}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW   ProRule:PRU00121}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000624-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        263..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..163
FT                   /note="FZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50038"
FT   DOMAIN          175..254
FT                   /note="Kringle"
FT                   /evidence="ECO:0000259|PROSITE:PS50070"
FT   DOMAIN          333..606
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          618..643
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        475
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000624-1"
FT   BINDING         339..347
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000624-2"
FT   BINDING         367
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000624-2"
SQ   SEQUENCE   690 AA;  77641 MW;  1F2C5CF873F30192 CRC64;
     MKTITATGVL FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI ACARFIGNRT IYVDSLQMQG
     EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD ARSRAPKPRE LCRDECEVLE
     SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC MRIGIPAERL GRYHQCYNGS
     GTDYRGTAST TKSGHQCQPW ALQHPHSHHL SSADFPELGG GHAYCRNPGG QMEGPWCFTQ
     NKNVRMELCD VPSCSPRDSS KMGILYILVP SIAIPLVIAC LFFLVCMCRN KQKASASTPQ
     RRQLMASPSQ DMEMPLINQH KQAKLKEISL SAVRFMEELG EDRFGKVYKG HLFGPTPGEQ
     TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNIICLL GVVTKDQPLS MIFSYCSHSD
     LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA AGMEYLSSHH VVHKDLATRN
     VLVYDKLNVK ISDLGLFREV YAADYYKLLG NSLLPIRWMA PEAIMYGKFS IDSDIWSYGV
     VLWEVFSYGL QPYCGYSNQD VVEMIRNRQV LPCPDDCPAW VYALMIECWN EFPSRRPRFK
     DIHSRLRAWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN AVRTRGSGRQ CWTMEMPNAL
     LWHNVSRVGS CWCLPGLADF EDEATDFGVM
//