ID A0A2K6DQA1_MACNE Unreviewed; 1290 AA.
AC A0A2K6DQA1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSMNEP00000038067.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSMNEP00000038067.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000038067.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000038067.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR Ensembl; ENSMNET00000062541.1; ENSMNEP00000038067.1; ENSMNEG00000042051.1.
DR GeneTree; ENSGT00940000154127; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000042051; Expressed in adult mammalian kidney and 8 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1290
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014432291"
FT TRANSMEM 279..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 40..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1146..1165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 445..472
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 689..716
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 989..1023
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1060..1094
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1290 AA; 145568 MW; A63A07A530593798 CRC64;
MGPSGSRGRA TWVLAGGLLA VALALGDRGC LDASSSPRWR PLGAQLPRHP QVAPGSGPGL
RTPPGRSGVG PESSTQDLPC MVWPKVECCH FKTAVEAPLG MKLDKKMEVF IPLSTSAASS
GPWAHSLFAF IPSWPKKNLF KRESPVTHRL YGDISREVQG TSENGVIFQK CALVSGPSEA
QTAHIWLLVN NTKTPSSANL SELLLLDSIA GLTVLESIGN KTSEGFQAFS KKFLQVGDAF
AVSYAATLQA GDLGNGESLK LPAQLTFQSS SQVLPHHGLH AAGFFIAFLL SLVLTWAALF
LMVHYQCLKG SMLTRHRVWQ YDSKLEPLPF TSADGVNEDL SLNDQMIDIL SSEDPGSMLQ
ALEELEIATL NRADADLEAC RTQISKDIIA LLLKNLTSSG HLSPQVERKM SDVFKKQFML
LENEIQEEYD RKMVALTAEC DLETRKKMEN QYQREMMAME EAEELLKRAS ERSAVECNSL
LRTLHGLEQE HLRKSLALQQ EEDFAKAHRQ LAVFQRNELH RIFFTQIKSA ILKGELKPEA
AKTLLQNYSK IQENVEELMD FFQASKRYHL SKRFGHREYL VQNLQSSETR VQGLLSTAAA
QLTHLIQKHE RAGYLDEDQM EMLLERAQTE VFSIKQKLDN DLKQEKKKLQ QKLITKRRRE
LLQKHREQRR EQLSISEAFQ AVEDAGQYLR QQRSLMEEQG AALEELQERL DQAALDDLRA
LTLSLFEKAT DELRRLQNSA MTQELLKRSV PWLFLQQILE EHGKEMAVRA EQLEGEERDR
DQEGVQSVRQ RLKDDAPEAA TEEQAELRRW EHLVFMKLCS SVFSLSEEEL LRMRQEVHGC
FAQMDRSLAL PKIRARVLLQ QFQTAWREAE FLKLDQALAA PELQQQSKVR KSRSKSKSKG
ELLKKCIEDK IHLCEEQASE DLVEKVRGEL LRERVQRLEA QEGGFAQSLV ALQFQKAARV
TETLSAYTAL LSIQDLLLEE LSASEMLTKS ACTQILESHS RELQELERKL EDQLVQQEAA
QQQQALASWQ QWVADGPGIL NEPGEVDSER QVSTVLQQAL SKSQTLLEQH QQSLREEQQN
SVVLEDLLEN MEADTFATLC SQELRLASYL ARMAVVPGAT LRRLLSVVLP TASQPQLLAL
LDSGSERHPD HAAEGDGGAE QADVGRRRKH QSWWQAFDSK LRGNLISRGL EKMLWARKRK
QSILKKSCLP LRERMIFSGK GSWPHLSLEP IGELAPVPIV GAETIDVLNT GEKLFIFRNP
KEPEISLHVP PRKKKNFLNA KKATRALGMD
//