ID A0A2K6DRP2_MACNE Unreviewed; 1068 AA.
AC A0A2K6DRP2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Formin like 2 {ECO:0000313|Ensembl:ENSMNEP00000038593.1};
GN Name=FMNL2 {ECO:0000313|Ensembl:ENSMNEP00000038593.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000038593.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000038593.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family.
CC {ECO:0000256|ARBA:ARBA00023449}.
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DR AlphaFoldDB; A0A2K6DRP2; -.
DR Ensembl; ENSMNET00000063074.1; ENSMNEP00000038593.1; ENSMNEG00000042052.1.
DR GeneTree; ENSGT00940000155515; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000042052; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:InterPro.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR043592; FMNL_animal.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45857; FORMIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR45857:SF5; FORMIN-LIKE PROTEIN 2; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 2.
DR Pfam; PF02181; FH2; 1.
DR PRINTS; PR00049; WILMSTUMOUR.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 1..441
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 592..983
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1015..1054
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 485..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 353..450
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 957..988
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 494..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..571
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 121495 MW; 71E5EDBCA0ED2275 CRC64;
APLKELPIWK PNAMNLPPDK ARLLRQYDNE KKWELICDQE RFQVKNPPHT YIQKLKGYLD
PAVTRKKFRR RVQESTQVLR ELEISLRTNH IGWVREFLNE ENKGLDVLVE YLSFAQYAVT
FDFESVESTV ESSVDKSKPW SRSIEDLHRG SNLPSPVGNS VSRSGRHSAL RYNTLPSRRT
LKNSRLVSKK DDVHVCIMCL RAIMNYQYGF NMVMSHPHAV NEIALSLNNK NPRTKALVLE
LLAAVCLVRG GHEIILSAFD NFKEVCGEKQ RFEKLMEHFR NEDNNIDFMV ASMQFINIVV
HSVEDMNFRV HLQYEFTKLG LDEYLDKLKH TESDKLQVQI QAYLDNVFDV GALLEDAETK
NAALERVEEL EENISHLSEK LQDTENEAMS KIVELEKQLM QRNKELDVVR EIYKDANTQV
HTLRKMVKEK EEAIQRQSTL EKKIHELEKQ GTIKIQKKGD GDIAILPVVA SGTLSMGSEV
VAGNSVGPTT GAASSGPLPP PPPPLPLSSD TPETVQNGPV TPPMPPPPPP PPPPPPPPPP
PPPPPPPLPG PVAETVPAPP LAPPLPSAPP LPGTSSPTVV FNSGLAGKTV KIKKPIKTKF
RMPVFNWVAL KPNQINGTVF NEIDDERILE DLNVDEFEEI FKTKAQGPAI DLSSSKQKIP
QKGSNKVTLL EANRAKNLAI TLRKAGKTAD EICKAIHVFD LKTLPVDFVE CLMRFLPTEN
EVKVLRLYER ERKPLENLSD EDRFMMQFSK IERLMQKMTI MAFIGNFAES IQMLTPQLHA
IIAASVSIKS SQKLKKILEI ILALGNYMNS SKRGAVYGFK LQSLDLLLDT KSTDRKQTLL
HYISNVVKEK YHQVSLFYNE LHYVEKAAAV SLENVLLDVK ELQRGMDLTK REYTMHDHNT
LLKEFILNNE GKLKKLQDDA KIAQDAFDDV VKYFGENPKT TPPSVFFPVF VRFVKAYKQA
EEENELRKKQ EQALMEKLLE QEALMEQQDP KSPSHKSKRQ QQELIAELRR RQVKDNRHVY
EGKDGAIEDI ITDLRNQPYR RADAVRRSVR RRFDDQNLRS VNGAEITM
//
