ID A0A2K6DT93_MACNE Unreviewed; 1615 AA.
AC A0A2K6DT93;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Formin homology 2 domain containing 3 {ECO:0000313|Ensembl:ENSMNEP00000039138.1};
GN Name=FHOD3 {ECO:0000313|Ensembl:ENSMNEP00000039138.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000039138.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000039138.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMNET00000063623.1; ENSMNEP00000039138.1; ENSMNEG00000042454.1.
DR GeneTree; ENSGT00940000154807; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000042454; Expressed in heart and 7 other cell types or tissues.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR041387; FHOD1_GBD_N.
DR InterPro; IPR014768; GBD/FH3_dom.
DR PANTHER; PTHR45920:SF3; FH1_FH2 DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45920; FORMIN HOMOLOGY 2 DOMAIN CONTAINING, ISOFORM I; 1.
DR Pfam; PF02181; FH2; 1.
DR Pfam; PF18382; Formin_GBD_N; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 18..411
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 1076..1472
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1552..1584
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 325..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1455..1498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1511..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1564..1603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..419
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..671
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 782..813
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1064
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1615 AA; 179065 MW; B2B272DD58D116BB CRC64;
MATLACRVQF LDDTDPFNST NFPEPSRPPL FTFREDLALG TQLAGVHRLL RAPHKLDDCT
LQLSHNGAYL DLEATLAEQR DELEGFQDDA GRGKKHSIIL RTQLSVRVHA CIEKLYNSSG
RDLRRALFSL KQIFQDDKDL VHEFVVAEGL TCLIKVGAEA DQNYQNYILR ALGQIMLYVD
GMNGVINHNE TIQWLYTLIG SKFRLVVKTA LKLLLVFVEY SESNAPLLIQ AVTAVDTKRG
VKPWSNIMEI LEEKDGVDTE LLVYAMTLVN KTLSGLPDQD TFYDVVDCLE ELGIAAVSQR
HLNKKGTDLD LVEQLNIYEV ALRHEDGDET AEPPPSGCRD RRRASVCSSG GGEHRGLDRR
RSRRHSVQSI KSTLSAPTSP CSQSAPSFKP SQVRDLREKE EEEEEEEQPI TEPNSEEERE
DDASCQGKDS KVSPASGQSP TGKDAAPKSS ALPAVSNASS QGKPLLAGTA GGTTRRSGSS
GPEAIPSALL SPPASAARPS SATPGSLKVS PTIDKLPYVP HSPFHLFSYD FEDSPLSTKE
KEAESQKESS SSDSVSLSTY SASEPYHFRS FSSNRYSNFG NNSHHSSRPS SGSSVPTTPT
SSVSPPQEAR LERSSPSGLL TSSFRQHQES LAAERERRRQ EREERLQRIE REERNKFSRD
YLDKREEQRQ AREERYKYLE QLAAEEHEKE LRSRSVSRGR ADLSLDLTSP AAPACPAPLS
HSPSSLDSQE AHTVSPSSPG TPHHPQASAG DPEPESEAEP EPEAGAGQVA DEAGQDIASA
HEGAETEVEQ ALEQEPEERA SLSEKERQNE GVNERDNCSA SSVSSSSSTL EREEKEDKLS
GDRTTGLWPA GVQDAGVNGQ CGDILTNKRF MLDMLYAHNR KTPGDEEKGD GEAGRTQQEA
EAVASLATRI STLQANSQTQ DESVRRVDVG CLDNRGSVKA FAEKFNSGDL GRGSVSPDAE
PNDKVPETVL VQPKTESDYI WDQLMANPRE LRIQDMDFTD LGEEDDIDVL DVDLSHREAP
GPPPPPPPTF LGLPPPPPPP LLDSIPPPPV PGNLLAPPPP VFSAPQGLGW SQVPRGQPTF
TKKKKTIRLF WNEVRPFDWP CKNNRRCREF LWSKLEPIKV DTSRLEHLFE SKSKELSVSK
KTAADGKRQE IIVLDSKRSN AINIGLTVLP PPRTIKIAIL NFDEYALNKE GIEKILTMIP
TDEEKQKIQE AQLANPEIPL GSAEQFLLTL SSISELSARL HLWAFKMDYE TTEKEVAEPL
LDLKEGIDQL ENNKTLGFIL STLLAIGNFL NGTNAKAFEL SYLEKVPEVK DTVHKQSLLH
HVCTMVVENF PDSSDLYSEI GAITRSAKVD FDQLQDNLCQ MERRCKASWD HLKAIAKHEM
KPVLKQRMSE FLKDCAERII ILKIVHRRII NRFHSFLLFM GHPPYAIREV NINKFCRIIS
EFALEYRTTR ERVLQQKQKR ANHRERNKTR GKMITDSGKF SGSSPAPPSQ PQGLSYAEDA
AEHENMKAVL QTSSPSVEDA APALGVRTRS RASRGSTSSW TMGTDDSPNV TDDAADEIMD
RIVKSATQVP SQRVVPRERK RSRANRKSLR RTLKSGLTPE EARALGLVGT SELQL
//
