ID A0A2K6DTN7_MACNE Unreviewed; 711 AA.
AC A0A2K6DTN7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=RAP1 GTPase activating protein 2 {ECO:0000313|Ensembl:ENSMNEP00000039291.1};
GN Name=RAP1GAP2 {ECO:0000313|Ensembl:ENSMNEP00000039291.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000039291.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000039291.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011722860.1; XM_011724558.1.
DR RefSeq; XP_011722865.1; XM_011724563.1.
DR AlphaFoldDB; A0A2K6DTN7; -.
DR Ensembl; ENSMNET00000063777.1; ENSMNEP00000039291.1; ENSMNEG00000042587.1.
DR GeneID; 105471797; -.
DR CTD; 23108; -.
DR GeneTree; ENSGT00940000160935; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000042587; Expressed in heart and 9 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 6.10.140.210; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF17; RAP1 GTPASE-ACTIVATING PROTEIN 2; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 229..445
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..630
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 711 AA; 77939 MW; C14D55F172F5AB8D CRC64;
MLASLKVKKQ ELANSSDVTL PDRPLSPPLT APPTMKSSEF FEMLEKMQGI KLEEQKPGPQ
KNKDDYIPYP SIDEVVEKGG PYPQVILPQF GGYWIEDPEN VGTPTSLGSS ICEEEEEDNL
SPNTFGYKLE CKGEARAYRR HFLGKDHLNF YCTGSSLGNL ILSVKCEEAE GIEYLRIILR
SKLKTVHERI PLAGLSKLPS VPQIAKAFCD DAVGLRFNPV LYPKASQMIV SYDEHEVNNT
FKFGVIYQKA RQTLEEELFG NNEESPAFKE FLDLLGDTIT LQDFKGFRGG LDVTHGQTGV
ESVYTTFRDR EIMFHVSTKL PFTEGDTQQL QRKRHIGNDI VAIIFQEENT PFVPDMIASN
FLHAYIVVQV ETPGTETPSY KVSVTAREDV PTFGPPLPSP PVFQKGPDFR EFLLTKLTNA
ENACCKSDKF AKLEDRTRAA LLDNLHDELH AHTQAMLGLG PEEDKFENGG HGGFLESFKR
AIRVRSHSME TMVGGQKKSH SGGIPGSLSG GISHNSMEVT KTTFSPPVVA ATAKNQSRSP
IKRRSGLFPR LHTGSEGQGD SRARCDSTSS TPKTPDGGHS SQEIKSETSS NPSSPEICPN
KEKPFMKLKE NGRAISRSSS STSSVSSTAG EGEAMEEGDS GSSQPSTTSP FRQEVFVYSP
SPSGESPSLG AAATPIIMGR SPTDAKSRNS PRSNLKFRFD KLSHASSGAG H
//
