ID A0A2K6DUH2_MACNE Unreviewed; 557 AA.
AC A0A2K6DUH2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ankyrin repeat and SOCS box containing 3 {ECO:0000313|Ensembl:ENSMNEP00000039550.1};
GN Name=ASB3 {ECO:0000313|Ensembl:ENSMNEP00000039550.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000039550.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000039550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR AlphaFoldDB; A0A2K6DUH2; -.
DR STRING; 9545.ENSMNEP00000039550; -.
DR Ensembl; ENSMNET00000064038.1; ENSMNEP00000039550.1; ENSMNEG00000042717.1.
DR GeneTree; ENSGT00940000159080; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000042717; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03722; SOCS_ASB3; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037329; ASB3_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24178:SF9; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 117..149
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 150..182
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 184..216
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 217..249
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 250..282
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 480..543
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 557 AA; 61978 MW; 430B00D980C75C50 CRC64;
MAMMPLVLHH PERQAELGSG LRDGGGGEAL RPPGRLVKQM DFTEAYADTC STVGLAAREG
NVKVLRKLLK KGRSVDVADN RGWMPIHEAA YHNSVECLQM LINADSSENY IKMKTFEGFC
ALHLAASQGH WKIVQILLEA GADPNATTLE ETTPLFLAVE NGQIDVLKLL LQHGANVNGS
HSMCGWNSLH QASFQENAEI IKLLLKKGAN KECQDDFGIT PLFVAAQYGK LESLSILISS
GANVNCQALD KATPLFIAAQ EGHTKCVELL LSSGADPDLY CNEDNWQLPI HAAAQMGHTK
ILDLLIPLTN RACDTELNKV SPVYSAVFGG HEDCLEILLR NGYSPDAQAC LVFGFSSPVC
MAFQKDCEFF GIVNILLKYG ARINELHLAY CLKYEKFSIF RYFLRKGCSL GPWNHIYEFV
NHAIKAQAKY KEWLPHLLVA GFDPQILLCS SWIDSVSIDT LTFTLEFTNW KTLPPAVERM
LSARASNAWI LQQHIATIPS LTHLCRLEIR SSLKSERLRS DSYISELPLP RSLHNYLLYE
DVLRMYEVPE LAAIQDG
//
