ID A0A2K6DVL6_MACNE Unreviewed; 657 AA.
AC A0A2K6DVL6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Zinc finger protein 133 {ECO:0000313|Ensembl:ENSMNEP00000039959.1};
GN Name=ZNF133 {ECO:0000313|Ensembl:ENSMNEP00000039959.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000039959.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000039959.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR RefSeq; XP_011748209.1; XM_011749907.1.
DR RefSeq; XP_011748210.1; XM_011749908.1.
DR AlphaFoldDB; A0A2K6DVL6; -.
DR Ensembl; ENSMNET00000064450.1; ENSMNEP00000039959.1; ENSMNEG00000042900.1.
DR GeneID; 105486837; -.
DR KEGG; mni:105486837; -.
DR CTD; 7692; -.
DR GeneTree; ENSGT00940000162260; -.
DR OMA; CKECGWC; -.
DR OrthoDB; 5246158at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000042900; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24379; KRAB AND ZINC FINGER DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24379:SF77; ZINC FINGER PROTEIN 696; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 4..75
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 217..244
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 245..272
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 273..300
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 301..328
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 329..356
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 357..384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 385..412
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 413..440
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 441..468
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 469..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..524
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 525..552
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 553..580
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 581..608
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 609..639
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 121..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 657 AA; 73645 MW; 03FC5DAE9ED3941E CRC64;
MAHMAFRDVA VDFTQDEWRL LSPAQRTLYR EVMLENYSNL VSLGISFSKP ELITQLEQGK
ETWREEKNCS PATCPADPEP ELYLDPFCPP GFSSQKFPMQ HVLCNHPPWI FTCLCTEGDV
QPGDPGPGDE QKQPQASEGR PWSDEAEGPG GEGARPLFGR TKKRTLGAFS RPPQRQPVTS
RNSLRGVELE ASPAPTGNPE ETDKLLKRIE VLGFGTVNCG ECGLSFSKMT NLLSHQRIHS
GEKPYVCGVC EKGFSLKKSL ARHQKAHSGE KQIVCSECGR GFNRKSTLII HERTHSGEKP
YMCSECGRGF SQKSNLIIHQ RTHSGEKPYV CRECGKGFSQ KSAVVRHQRT HLEEKTIVCS
DCGLGFSDRS NLISHQRTHS GEKPYACKEC GRCFRQRTTL VNHQRTHSKE KPYVCGVCGH
SFSQNSTLIS HRRTHTGEKP YVCGVCGRGF SLKSHLNRHQ NIHSGEKPIV CKDCGRGFSQ
QSNLIRHQRT HSGEKPMVCG ECGRGFSQKS NLVAHQRTHS GERPYVCREC GRGFSHQAGL
IRHKRKHSRE KPYMCRQCGL GFGNKSALIT HKRAHLEEKP CVCRECGQGF LQKSHLTLHQ
MAHKGEKPYV CKTCGQGFSL KSHLSRHRKT TSVHHRLPPH PDPEPCAGQP SDSLYSL
//
