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Database: UniProt
Entry: A0A2K6DZT7_MACNE
LinkDB: A0A2K6DZT7_MACNE
Original site: A0A2K6DZT7_MACNE 
ID   A0A2K6DZT7_MACNE        Unreviewed;      1045 AA.
AC   A0A2K6DZT7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=FBH1 {ECO:0000313|Ensembl:ENSMNEP00000041422.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041422.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000041422.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   AlphaFoldDB; A0A2K6DZT7; -.
DR   Ensembl; ENSMNET00000065920.1; ENSMNEP00000041422.1; ENSMNEG00000043475.1.
DR   GeneTree; ENSGT00390000011669; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000043475; Expressed in bone marrow and 12 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd22095; F-box_FBXO18; 1.
DR   CDD; cd18786; SF1_C; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          211..260
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   REGION          28..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  118185 MW;  9E53C42CF867C2AE CRC64;
     MRRFKRKHLT AIDCQHLARS HLSVTQPFGQ RWTNRDPNHG LYPKPRTKRG SRGQGRQRCI
     PEFFLAGKRP CTNDMAKSNS VGQDSCQDSE GDMIFPAESS CALPQEGSGE AWLGSSGSAP
     PSRKRSRSSE EESNQATGTS RWDGVSKKAP RHHLIVPCTR PREARQEAED STSRLSEESG
     ETDQDAGDMG PDPIPDSYYG LLGTLPCQEA PSHICSLPSE VLRHVFAFLP VEDLYWNLSL
     VCHLWREIIS DPLFIPWKKL YHRYLMNEEQ AVSKVDGILS NCGIEKESDL CVLNLIRYTA
     TTKCSPSVDP ERVLWSLRDH PLLPEAEACV RQHLPDLYTA AGGVNVWALV AAVVLLSSSV
     NDIQQLLFCL RRPSSTVTMP DVTETLYCIA VLLYAMREKG INISNRIHYN IFYCLYLQEN
     SCTQATKVKE EPSVWPGKKT IQLTHEQQLI LNHKMEPLQV VKIMAFAGTG KTSTLVKYAE
     KWSQSRFLYV TFNKSIAKQA ERVFPSNVIC KTFHSMAYGH IGRKYQSKKK LNLFKLTPFM
     VNSVLAEGKG GFIRAKLVCK TLENFFASAD EELTIDHVPI WCKNSQGQRV MVEQSEKLNG
     VLEASRLWDN MRKLGECTEE AYQMTHDGYL KLWQLSKPLL ASFDAIFVDE AQDCTPAIMN
     IVLSQPCGKI FVGDPHQQIY TFRGAVNALF TVPHTHVFYL TQSFRFGVEI AYVGATILDV
     CKRVRKKTLV GGNHQSGIRG DAKGQVALLS RTNANVFDEA VRVTEGEVPS RIHLIGGIKS
     FGLDRIIDIW ILLQPEEERR KQNLVIKDRF IRRWVHKEGF SGFKRYVTAA EDKELEAKIA
     VVEKYNIRIP ELVQRIEKCH IEDLDFAEYI LGTVHKAKGL EFDTVHVLDD FVKVPCARHN
     LPQLPHFRVE SFSEDEWNLL YVAVTRAKKR LIMTKSLENI LTLAGEYFLQ AELTSNVLKT
     GVVRCCVGQC NNAIPVDTVL TMKKLAITYS NRKENKGGYL CHSCAEQRIG PLAFLTASPE
     QVRAMERTVE NIVLPRHEAL LFLVF
//
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