ID A0A2K6DZT7_MACNE Unreviewed; 1045 AA.
AC A0A2K6DZT7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=FBH1 {ECO:0000313|Ensembl:ENSMNEP00000041422.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041422.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000041422.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR AlphaFoldDB; A0A2K6DZT7; -.
DR Ensembl; ENSMNET00000065920.1; ENSMNEP00000041422.1; ENSMNEG00000043475.1.
DR GeneTree; ENSGT00390000011669; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043475; Expressed in bone marrow and 12 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd22095; F-box_FBXO18; 1.
DR CDD; cd18786; SF1_C; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 211..260
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 28..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 118185 MW; 9E53C42CF867C2AE CRC64;
MRRFKRKHLT AIDCQHLARS HLSVTQPFGQ RWTNRDPNHG LYPKPRTKRG SRGQGRQRCI
PEFFLAGKRP CTNDMAKSNS VGQDSCQDSE GDMIFPAESS CALPQEGSGE AWLGSSGSAP
PSRKRSRSSE EESNQATGTS RWDGVSKKAP RHHLIVPCTR PREARQEAED STSRLSEESG
ETDQDAGDMG PDPIPDSYYG LLGTLPCQEA PSHICSLPSE VLRHVFAFLP VEDLYWNLSL
VCHLWREIIS DPLFIPWKKL YHRYLMNEEQ AVSKVDGILS NCGIEKESDL CVLNLIRYTA
TTKCSPSVDP ERVLWSLRDH PLLPEAEACV RQHLPDLYTA AGGVNVWALV AAVVLLSSSV
NDIQQLLFCL RRPSSTVTMP DVTETLYCIA VLLYAMREKG INISNRIHYN IFYCLYLQEN
SCTQATKVKE EPSVWPGKKT IQLTHEQQLI LNHKMEPLQV VKIMAFAGTG KTSTLVKYAE
KWSQSRFLYV TFNKSIAKQA ERVFPSNVIC KTFHSMAYGH IGRKYQSKKK LNLFKLTPFM
VNSVLAEGKG GFIRAKLVCK TLENFFASAD EELTIDHVPI WCKNSQGQRV MVEQSEKLNG
VLEASRLWDN MRKLGECTEE AYQMTHDGYL KLWQLSKPLL ASFDAIFVDE AQDCTPAIMN
IVLSQPCGKI FVGDPHQQIY TFRGAVNALF TVPHTHVFYL TQSFRFGVEI AYVGATILDV
CKRVRKKTLV GGNHQSGIRG DAKGQVALLS RTNANVFDEA VRVTEGEVPS RIHLIGGIKS
FGLDRIIDIW ILLQPEEERR KQNLVIKDRF IRRWVHKEGF SGFKRYVTAA EDKELEAKIA
VVEKYNIRIP ELVQRIEKCH IEDLDFAEYI LGTVHKAKGL EFDTVHVLDD FVKVPCARHN
LPQLPHFRVE SFSEDEWNLL YVAVTRAKKR LIMTKSLENI LTLAGEYFLQ AELTSNVLKT
GVVRCCVGQC NNAIPVDTVL TMKKLAITYS NRKENKGGYL CHSCAEQRIG PLAFLTASPE
QVRAMERTVE NIVLPRHEAL LFLVF
//