ID A0A2K6DZY1_MACNE Unreviewed; 1159 AA.
AC A0A2K6DZY1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN Name=WDR35 {ECO:0000313|Ensembl:ENSMNEP00000041467.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041467.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000041467.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC required for retrograde ciliary transport and entry into cilia of G
CC protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR AlphaFoldDB; A0A2K6DZY1; -.
DR Ensembl; ENSMNET00000065965.1; ENSMNEP00000041467.1; ENSMNEG00000043506.1.
DR GeneTree; ENSGT00940000155745; -.
DR OMA; RLNCIAW; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043506; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR PANTHER; PTHR12764:SF5; WD REPEAT-CONTAINING PROTEIN 55 HOMOLOG; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 130..194
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1159 AA; 131009 MW; F6CB53328BCF200A CRC64;
MFFYLTKKIS IPNNVKLKCV SWNKEQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAAPSN
LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD ENGLIIVWML YKGSWFEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLS HVTWSADSKV LLFGMANGEI
HIYDNQGNFI MKMKLSCLVN VTGAISIAGI HWYHGTEGYV EPDCPCLAVC FDNGRCQIMR
HENDQNPVLI DTGMYVVGIQ WNHMGSVLAV AGFQKAAAQD KDVNIVQFYT PFGEHLGTLK
VPGKEISALS WEGGGLKIAL AVDSFIYFAN IRPNYKWGYC SNTVVYAYTR PDRPEHCVVF
WDTKNNEKHV KYVKGLISIT TCGDFCILAT KADENHPQVG AFAAQTFLPL FVAMTKTHVI
AASKEAFYTW QYRVAKKLTA LEINQITRSR KEGRERIYHV DDTPSGSMDG VLDYSKAIQG
TRDPICAITA SDKILIVGRE SGTIQRYSLP NVGLIQKYSL NCRGYQLSLN CNSSRLAIID
ISGVLTFFDL DARVTDSTGQ QVVGELLKLE RRDVWDMKWA KDNPDLFAMM EKTRMYVFRN
LDPEEPIQTS GYICNFEDLE IKSVLLDEIL KDPEHPNKDY LINFEIRSLR DSRALIEKVG
IKDASQFIED NPHPRLWRLL AEAALQKLDL YTAEQAFVRC KDYQGIKFVK RLGKLLSESM
KQAEVVGYFG RFEEAERTYL EMDRRDLAIG LRLKLGDWFR VLQLLKTGSG DADDSLMEQA
NNAIGDYFAD RQKWLNAVQY YVQGRNQERL AECYYMLEDY EGLENLAVSL PENHKLLPEI
AQMFVRVGMC EQAVTAFLKC NQPKAAVDTC VHLNQWNKAV ELAQNHSMKE IGSLLARYAS
HLLEKNKTLD AIELYRKANY FFDAAKLMFK IADEEAKKGS KPLRVKKLYV LSALLIEQYH
EQMKNAQRGK VKGKSSEATS ALAGLLEEEV LSTTDRFTDN AWRGAEAYHF FILAQRQLYE
GYVDTALKTA LHLKDYEDII PPVEIYSLLA LCACASRAFG TCSKAFIKLK SLETLSSEQK
QQYEDLALEI FTKHTSKDNR KPELDSLMEG GEGKLPTCVA TGSPITEYQF WMCSVCKHGV
LAQEISHYSF CPLCHSPVA
//