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Database: UniProt
Entry: A0A2K6DZY1_MACNE
LinkDB: A0A2K6DZY1_MACNE
Original site: A0A2K6DZY1_MACNE 
ID   A0A2K6DZY1_MACNE        Unreviewed;      1159 AA.
AC   A0A2K6DZY1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN   Name=WDR35 {ECO:0000313|Ensembl:ENSMNEP00000041467.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041467.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000041467.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC       required for retrograde ciliary transport and entry into cilia of G
CC       protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC       ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR   AlphaFoldDB; A0A2K6DZY1; -.
DR   Ensembl; ENSMNET00000065965.1; ENSMNEP00000041467.1; ENSMNEG00000043506.1.
DR   GeneTree; ENSGT00940000155745; -.
DR   OMA; RLNCIAW; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000043506; Expressed in pituitary gland and 12 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR   GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.40.470; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR024977; Apc4-like_WD40_dom.
DR   InterPro; IPR039857; Ift122/121.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR017233; WDR35.
DR   PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR   PANTHER; PTHR12764:SF5; WD REPEAT-CONTAINING PROTEIN 55 HOMOLOG; 1.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 1.
DR   PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW   Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW   Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW   Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   REPEAT          67..98
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          130..194
FT                   /note="Anaphase-promoting complex subunit 4-like WD40"
FT                   /evidence="ECO:0000259|Pfam:PF12894"
SQ   SEQUENCE   1159 AA;  131009 MW;  F6CB53328BCF200A CRC64;
     MFFYLTKKIS IPNNVKLKCV SWNKEQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAAPSN
     LSMNQTLEGH SGSVQVVTWN EQYQKLTTSD ENGLIIVWML YKGSWFEEMI NNRNKSVVRS
     MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGIQLS HVTWSADSKV LLFGMANGEI
     HIYDNQGNFI MKMKLSCLVN VTGAISIAGI HWYHGTEGYV EPDCPCLAVC FDNGRCQIMR
     HENDQNPVLI DTGMYVVGIQ WNHMGSVLAV AGFQKAAAQD KDVNIVQFYT PFGEHLGTLK
     VPGKEISALS WEGGGLKIAL AVDSFIYFAN IRPNYKWGYC SNTVVYAYTR PDRPEHCVVF
     WDTKNNEKHV KYVKGLISIT TCGDFCILAT KADENHPQVG AFAAQTFLPL FVAMTKTHVI
     AASKEAFYTW QYRVAKKLTA LEINQITRSR KEGRERIYHV DDTPSGSMDG VLDYSKAIQG
     TRDPICAITA SDKILIVGRE SGTIQRYSLP NVGLIQKYSL NCRGYQLSLN CNSSRLAIID
     ISGVLTFFDL DARVTDSTGQ QVVGELLKLE RRDVWDMKWA KDNPDLFAMM EKTRMYVFRN
     LDPEEPIQTS GYICNFEDLE IKSVLLDEIL KDPEHPNKDY LINFEIRSLR DSRALIEKVG
     IKDASQFIED NPHPRLWRLL AEAALQKLDL YTAEQAFVRC KDYQGIKFVK RLGKLLSESM
     KQAEVVGYFG RFEEAERTYL EMDRRDLAIG LRLKLGDWFR VLQLLKTGSG DADDSLMEQA
     NNAIGDYFAD RQKWLNAVQY YVQGRNQERL AECYYMLEDY EGLENLAVSL PENHKLLPEI
     AQMFVRVGMC EQAVTAFLKC NQPKAAVDTC VHLNQWNKAV ELAQNHSMKE IGSLLARYAS
     HLLEKNKTLD AIELYRKANY FFDAAKLMFK IADEEAKKGS KPLRVKKLYV LSALLIEQYH
     EQMKNAQRGK VKGKSSEATS ALAGLLEEEV LSTTDRFTDN AWRGAEAYHF FILAQRQLYE
     GYVDTALKTA LHLKDYEDII PPVEIYSLLA LCACASRAFG TCSKAFIKLK SLETLSSEQK
     QQYEDLALEI FTKHTSKDNR KPELDSLMEG GEGKLPTCVA TGSPITEYQF WMCSVCKHGV
     LAQEISHYSF CPLCHSPVA
//
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