ID A0A2K6E084_MACNE Unreviewed; 767 AA.
AC A0A2K6E084;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Pleckstrin and Sec7 domain containing 2 {ECO:0000313|Ensembl:ENSMNEP00000041571.1};
GN Name=PSD2 {ECO:0000313|Ensembl:ENSMNEP00000041571.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041571.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000041571.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle membrane
CC {ECO:0000256|ARBA:ARBA00004632}.
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DR AlphaFoldDB; A0A2K6E084; -.
DR STRING; 9545.ENSMNEP00000041571; -.
DR Ensembl; ENSMNET00000066070.1; ENSMNEP00000041571.1; ENSMNEG00000043579.1.
DR GeneTree; ENSGT00940000159674; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043579; Expressed in temporal lobe and 1 other cell type or tissue.
DR GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF329; PH AND SEC7 DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 289..462
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 512..625
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 653..680
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..767
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 84027 MW; C56EB2DB24E66A6B CRC64;
MEEDKLLSAV PEEGDATHDP SPEPEEEPGV QNGMASEGLN SSLCSPGHER RGTPADTEEP
TKDPDMAFRG LSLGLSLTNG LALGPDLNIL EDSTGSRSWR AGVLAEGDDA SRSLCPDAED
PQLELDGPGE PDVRDGFSAT FEKILESELL RGTQYSSLDS LDGLSLTDES DSCVSFEAPL
TPLIQQRARD SPEPGAGLGI GDMGFEGDMG AAGGDGELGS PLRRSISSSR SENVLSRLSL
MAMPNGFHED GPQGPGGDED DDEEDTDKLL NSTSDPSLKD GLSDSDSELS SSEGLEPGSA
DPLANGCQGV SEAARRLARR LYHLEGFQRC DVARQLGKNN EFSRLVAGEY LSFFDFSGLT
LDRALRTFLK AFPLMGETQE RERVLTHFSR RYCQCNPDDS TSEDGIHTLT CALMLLNTDL
HGHNIGKKMS CQQFIANLDQ LNDGQDFAKD LLKTLYNSIK NEKLEWAIDE DELRKSLSEL
VDDKFGTGTK KVTRILDGGN PFLDVPQALS ATTYKHGVLT RKTHADMDGK RTPRGRRGWK
KFYAVLKGTI LYLQKDEYRP DKALSEGDLK NAIRVHHALA TRASDYSKKS NVLKLKTADW
RVFLFQAPSK EEMLSWILRI NLVAAIFSAP AFPAAVSSMK KFCRPLLPSC TTRLCQEEQL
RSHENKLRQL TAELAEHRCH PVERGIKSKE AEEYRLKEHY LTFEVSLEGL DCKMIWSGLK
ARLAHLLTEG STASPPLRKS TLKSCPPPAQ GPLTGSKTTK DATGLNT
//
