ID A0A2K6E121_MACNE Unreviewed; 1713 AA.
AC A0A2K6E121;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Neurexin 2 {ECO:0000313|Ensembl:ENSMNEP00000041858.1};
GN Name=NRXN2 {ECO:0000313|Ensembl:ENSMNEP00000041858.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041858.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000041858.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_011718944.1; XM_011720642.1.
DR STRING; 9545.ENSMNEP00000041858; -.
DR Ensembl; ENSMNET00000066359.1; ENSMNEP00000041858.1; ENSMNEG00000043644.1.
DR GeneID; 105469526; -.
DR CTD; 9379; -.
DR GeneTree; ENSGT00940000155978; -.
DR OrthoDB; 2999458at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043644; Expressed in cerebellum and 1 other cell type or tissue.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:GOC.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:Ensembl.
DR GO; GO:0050839; F:cell adhesion molecule binding; IEA:Ensembl.
DR GO; GO:0097109; F:neuroligin family protein binding; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR GO; GO:0097116; P:gephyrin clustering involved in postsynaptic density assembly; IEA:Ensembl.
DR GO; GO:0097118; P:neuroligin clustering involved in postsynaptic membrane assembly; IEA:Ensembl.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0097119; P:postsynaptic density protein 95 clustering; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR GO; GO:0042297; P:vocal learning; IEA:Ensembl.
DR GO; GO:0071625; P:vocalization behavior; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF52; NEUREXIN-2; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1713
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014379227"
FT TRANSMEM 1639..1659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..207
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 203..243
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 290..487
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 494..687
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 691..728
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 733..905
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 919..1094
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1097..1134
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1138..1346
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1374..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1459..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1526..1627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1680..1713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1576..1602
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1713 AA; 185163 MW; EC81CAB15E89C4EE CRC64;
MAPGSRWRLP PPPPLLLLLL LALAARADGL EFGGGPGQWA RYARWAGAAS SGELSFSLRT
NATRALLLYL DDGGDCDFLE LLLVDGRLRL RFTLSCAEPA TLQLDTPVAD DRWHMVLLTR
DARRTALAVD GEARAAEVRS KRREMQVASD LFVGGIPPDV RLSALTLSTV KYEPPFRGLL
ANLKLGERPP ALLGSQGLRG ATADPLCAPA RNPCANGGLC TVLAPGEVGC DCSHTGFGGK
FCSEEEHPME GPAHLTLNSE VGSLLFSEGG AGRGGAGDVH QSTKGKEEFV ATFKGNEFFC
YDLSHNPIQS STDEITLAFR TLQRNGLMLH TGKSADYVNL SLKSGAVWLV INLGSGAFEA
LVEPVNGKFN DNAWHDVRVT RNLRQHAGIG HAMVNKLHYL VTISVDGILT TTGYTQEDYT
MLGSDDFFYI GGSPNTADLP GSPVSNNFMG CLKDVVYKNN DFKLELSRLA KEGDPKMKLQ
GDLSFRCEDV AALDPVTFES PEAFVALPRW SAKRTGSISL DFRTTEPNGL LLFSQGRRAE
GGAGSHSSAQ RADYFAMELL DGHLYLLLDM GSGGIKLRAS SRKVNDGEWC HVDFQRDGRK
GSISVNSRST PFLATGDSEI LDLESELYLG GLPEGGRVDL PLPPEVWTAA LRAGYVGCVR
DLFIDGRSRD LRGLAEAQGA VGVAPFCSRE TLKQCASAPC RNGGICREGW NRFVCDCIGT
GFLGRVCERE ATVLSYDGSM YMKIMLPNAM HTEAEDVSLR FMSQRAYGLM MATTSRESAD
TLRLELDGGQ MKLTVNLDCL RVGCAPSKGP ETLFAGHKLN DNEWHTVRVV RRGKSLQLSV
DNVTVEGQMA GAHTRLEFHN IETGIMTERR FISVVPSNFI GHLSGLVFNG QPYMDQCKDG
DITYCELNAR FGLRAIVADP VTFKSRSSYL ALATLQAYAS MHLFFQFKTT APDGLLLFNS
GNGNDFIVIE LVKGYIHYVF DLGNGPSLMK GNSDKPVNDN QWHNVVVSRD PGNVHTLKID
SRTVTQHSNG ARNLDLKGEL YIGGLSKNMF SNLPKLVASR DGFQGCLASV DLNGRLPDLI
ADALHRIGQV ERGCDGPSTT CTEESCANQG VCLQQWDGFT CDCTMTSYGG PVCNDPGTTY
IFGKGGALIT YTWPPNDRPS TRMDRLAVGF STHQRSAVLV RVDSASGLGD YLQLHIDQGT
VGVIFNVGTD DITIDEPNAI VSDGKYHVVR FTRSGGNATL QVDSWPVNER YPAGNFDNER
LAIARQRIPY RLGRVVDEWL LDKGRQLTIF NSQAAIKIGG RDQGRPFQGQ VSGLYYNGLK
VLALAAESDP NVRTEGHLRL VGEGPSVLLS AETTATTLLA DMATTIMETT TTMATTTTRR
GRSPTLRDST TQNTDDLLVA SAECPSDDED LEECEPSTGG ELILPIITED SLDPPPVATR
SPFVPPPPTF YPFLTGVGAT QDTLPPPAAR RPPSGGPCQA ERDDSDCEEP IEASGFASGE
VFDSSLPPTD DEDFYTTFPL VTDRTTLLSP RKPAPRPNLR TDGATGAPGV LFAPSAPAPN
LPAGKMNHRD PLQPLLENPP LGPGAPTSFE PRRPPPLRPG VTSAPGFPHL PTANPTGPGE
RGPPGAVEVI RESSSTTGMV VGIVAAAALC ILILLYAMYK YRNRDEGSYQ VDQSRNYISN
SAQSNGAVVK EKAPTAPKTP SKAKKNKDKE YYV
//
