ID A0A2K6E1A8_MACNE Unreviewed; 774 AA.
AC A0A2K6E1A8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Solute carrier family 26 member 9 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Anion transporter/exchanger protein 9 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A9 {ECO:0000313|Ensembl:ENSMNEP00000041953.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000041953.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000041953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Ion transporter that can act both as an ion channel and anion
CC exchanger. Mainly acts as a chloride channel, which mediate uncoupled
CC chloride anion transport in an alternate-access mechanism where a
CC saturable binding site is alternately exposed to either one or the
CC other side of the membrane. Also acts as a DIDS- and
CC thiosulfate- sensitive anion exchanger the exchange of chloride for
CC bicarbonate ions across the cell membrane.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A2K6E1A8; -.
DR Ensembl; ENSMNET00000066455.1; ENSMNEP00000041953.1; ENSMNEG00000043757.1.
DR GeneTree; ENSGT01100000263544; -.
DR OMA; WKDMMGT; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043757; Expressed in heart.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF17; SOLUTE CARRIER FAMILY 26 MEMBER 9; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 90..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 174..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 252..269
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 320..339
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 359..380
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 392..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 448..478
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 502..720
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 611..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 85057 MW; BD5963A338B4A5D6 CRC64;
MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNT FRCSSAKIKA VVFGLLPVLS
WLPKYKIKDY IVPDLLGGLS GGSIQVPQGM AFALLANLPA VNGLYSSFFP LLTYFFLGGV
HQMVPGTFAV ISILVGNICL QLAPESKFQV FNNATNESYV DTAAMEAERL HVSATLACLT
AIIQIGLGFM QFGFVAIYLS ESFIRGFMTA AGLQILISVL KYIFGLTIPS YAGPGSIVFT
FIDICKNLPH TNIASLIFAL ISGAFLVLVK ELNARYMHKI RFPIPTEMIV VRTPPSGLLG
RFPTPVSPVV SQWKDMIGTA FSLAIVGYVI NLAMGRTLAN KHGYDVDSNQ EMIALGCSNF
FGSFFKIHVI CCALSVTLAV DGAGGKSQVA SLCVSLVVMI TMLVLGTYLY PLPKSVLGAL
IAVNLKNSLK QLTDPYYLWR KSKLDCCIWV VSFLSSFFLS LPYGVAVGVA FSVLVVVFQT
QFRNGYALAQ VMDTDIYVNP KTYNRAQDIQ GIKIITYCSP LYFANSEIFR QKVIAKTGMD
PQKVLLAKQK YLKKQEKRRM RPTQQRRSLF MKTKTVSLQE LQQDFENASP TDPNNNQTQA
NGTSVSYITF SPDSSSAAQS EPPASAEAPG EPSDTLASVP PFVTFHTLIL DMSGVSFVDL
MGIKTLAKLS STYGKIGVKV FLVNIHAQVY NDISHGGVFE DGSLECKHVF PSIHDAVLFA
QANARDVTPG HNFQGAPGDP ELSLYDSEED IPSYWDLEQE MFGSMFHTET LTAL
//