ID A0A2K6E1P7_MACNE Unreviewed; 510 AA.
AC A0A2K6E1P7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Butyrophilin subfamily 3 member A1 {ECO:0000313|Ensembl:ENSMNEP00000042098.1};
GN Name=BTN3A1 {ECO:0000313|Ensembl:ENSMNEP00000042098.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000042098.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000042098.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000256|ARBA:ARBA00007591}.
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DR AlphaFoldDB; A0A2K6E1P7; -.
DR STRING; 9545.ENSMNEP00000042098; -.
DR Ensembl; ENSMNET00000066600.1; ENSMNEP00000042098.1; ENSMNEG00000043821.1.
DR GeneTree; ENSGT00940000163036; -.
DR OMA; NIMKNCL; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043821; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0050798; P:activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
DR CDD; cd05713; IgV_MOG_like; 1.
DR CDD; cd15820; SPRY_PRY_BTN3; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR037954; SPRY_PRY_BTN3.
DR PANTHER; PTHR24100; BUTYROPHILIN; 1.
DR PANTHER; PTHR24100:SF128; BUTYROPHILIN SUBFAMILY 3 MEMBER A1; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00409; IG; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..510
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014399346"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..135
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 160..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 318..510
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
SQ SEQUENCE 510 AA; 57386 MW; 4B0D8AF078A872F6 CRC64;
MKMGNFLAFL LLNFHVCVLL LQLLMPHSAQ FAVVGPPGPI LAMVGEDADL PCHLFPTMSA
ETMELRWVSS NLRQVVNVYA DGKEVEDRQS AAYRGRTDGI TAGKAALRIH NVTASDSGKY
LCYFQDGDFY EKALVELKVA ALGSDLHIDV KGYEDGGIHL ECRSTGWYPQ PQIRWSNDKG
ENIPAVEAPV FVDGVGLYAV AASVILRGSS GEGVSCTIRS SLLGLEKTTS ISIAGPFFRR
AQSWIAALAG TLPVLLLLLG GAGYFLWRQQ EEKKTLFRKK KREQELRELA WSTVKQEKST
REKLLEEIRW RSMQYTVLGE RPSAYNEWKK ALFKPADVIL DPKTANPILL VSEDQRSVQR
AKEPQDLPDN PERFDWHYCV LGCESFMSGR HYWEVEVGDR KEWHIGVCSK NVQRKGWVKM
TPENGFWTMG LTDGKKYRTL TEPRTNLELP ESPRKVGVFL DYETGDISFY NAVNGSHIHT
FLDVSFSEPL YPVFRILTLE PTALTICPAP
//
