ID A0A2K6E1Z6_MACNE Unreviewed; 198 AA.
AC A0A2K6E1Z6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Bcl-2-like protein 11 {ECO:0000256|PIRNR:PIRNR037827};
DE Short=Bcl2-L-11 {ECO:0000256|PIRNR:PIRNR037827};
DE AltName: Full=Bcl2-interacting mediator of cell death {ECO:0000256|PIRNR:PIRNR037827};
GN Name=BCL2L11 {ECO:0000313|Ensembl:ENSMNEP00000042198.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000042198.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000042198.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Induces apoptosis and anoikis.
CC {ECO:0000256|PIRNR:PIRNR037827}.
CC -!- SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2
CC proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
CC {ECO:0000256|PIRNR:PIRNR037827}.
CC -!- SIMILARITY: Belongs to the Bcl-2 family.
CC {ECO:0000256|PIRNR:PIRNR037827}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR SMR; A0A2K6E1Z6; -.
DR STRING; 9545.ENSMNEP00000042182; -.
DR Ensembl; ENSMNET00000066684.1; ENSMNEP00000042182.1; ENSMNEG00000043857.1.
DR Ensembl; ENSMNET00000066700.1; ENSMNEP00000042198.1; ENSMNEG00000043857.1.
DR GeneTree; ENSGT00390000003178; -.
DR OMA; EIWIARE; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043857; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0097136; C:Bcl-2 family protein complex; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-UniRule.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:UniProtKB-UniRule.
DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR InterPro; IPR014771; Apoptosis_Bim_N.
DR InterPro; IPR017288; Bcl-2-like_11.
DR InterPro; IPR015040; Bcl-x_interacting_BH3_dom.
DR PANTHER; PTHR12044:SF9; BCL-2-LIKE PROTEIN 11; 1.
DR PANTHER; PTHR12044; BCL2 INTERACTING MEDIATOR OF CELL DEATH; 1.
DR Pfam; PF08945; Bclx_interact; 1.
DR Pfam; PF06773; Bim_N; 1.
DR PIRSF; PIRSF037827; Bcl-2-like_p11; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|PIRNR:PIRNR037827};
KW Membrane {ECO:0000256|PIRNR:PIRNR037827};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR037827};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 4..40
FT /note="Apoptosis Bim N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06773"
FT DOMAIN 134..166
FT /note="Bcl-x interacting BH3"
FT /evidence="ECO:0000259|Pfam:PF08945"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 22138 MW; C5D5A79DA6ECB427 CRC64;
MAKQPSDVSS ECDREGRQLQ PAERPPQLRP GAPTSLQTEP QGNPEGNHGG EGDSCPHGSP
QGPLAPPASP GPFATRSPLF IFMRRSSLLS RSSSGYFSFD TDRSPAPMSC DKSTQTPSPP
CQAFNHYLSA MASRRQAEPA DMRPEIRIAQ ELRRIGDEFN AYYARRVFLN NYQAAEDHPQ
MVILRLLRYI VRLVWRMH
//
