ID A0A2K6E2U1_MACNE Unreviewed; 96 AA.
AC A0A2K6E2U1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=C-C motif chemokine {ECO:0000256|RuleBase:RU361150};
GN Name=CCL1 {ECO:0000313|Ensembl:ENSMNEP00000042482.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000042482.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000042482.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361150}.
CC -!- SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
CC {ECO:0000256|ARBA:ARBA00010868, ECO:0000256|RuleBase:RU361150}.
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DR RefSeq; XP_011745681.1; XM_011747379.1.
DR AlphaFoldDB; A0A2K6E2U1; -.
DR STRING; 9545.ENSMNEP00000042482; -.
DR Ensembl; ENSMNET00000066985.1; ENSMNEP00000042482.1; ENSMNEG00000043966.1.
DR GeneID; 105485157; -.
DR KEGG; mni:105485157; -.
DR CTD; 6346; -.
DR GeneTree; ENSGT01100000263482; -.
DR OMA; MHVSSSN; -.
DR OrthoDB; 4558017at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0032740; P:positive regulation of interleukin-17 production; IEA:Ensembl.
DR GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Ensembl.
DR CDD; cd00272; Chemokine_CC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR000827; Chemokine_CC_CS.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015:SF5; C-C MOTIF CHEMOKINE 1; 1.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
DR PROSITE; PS00472; SMALL_CYTOKINES_CC; 1.
PE 3: Inferred from homology;
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500, ECO:0000256|RuleBase:RU361150};
KW Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU361150};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU361150};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU361150}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|RuleBase:RU361150"
FT CHAIN 24..96
FT /note="C-C motif chemokine"
FT /evidence="ECO:0000256|RuleBase:RU361150"
FT /id="PRO_5014209643"
FT DOMAIN 30..88
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 96 AA; 10950 MW; 711856D0CB10F6EF CRC64;
MQIITTALVC LLLAGMWPQD VDSKSMQVPF SRCCFSFVEK EISLRAIQCY RNTSSSCSNE
GLIFKLKRGN EACALNQARW VQNHIKKLSH CLPKRK
//
