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Database: UniProt
Entry: A0A2K6E5W3_MACNE
LinkDB: A0A2K6E5W3_MACNE
Original site: A0A2K6E5W3_MACNE 
ID   A0A2K6E5W3_MACNE        Unreviewed;      1253 AA.
AC   A0A2K6E5W3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Ras protein specific guanine nucleotide releasing factor 1 {ECO:0000313|Ensembl:ENSMNEP00000043548.1};
GN   Name=RASGRF1 {ECO:0000313|Ensembl:ENSMNEP00000043548.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000043548.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000043548.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K6E5W3; -.
DR   Ensembl; ENSMNET00000068056.1; ENSMNEP00000043548.1; ENSMNEG00000044392.1.
DR   GeneTree; ENSGT00940000157599; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000044392; Expressed in cerebellum and 3 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd13261; PH_RasGRF1_2; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR   Pfam; PF00169; PH; 2.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 2.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          22..129
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          240..406
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          447..564
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          624..742
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          1018..1250
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          704..734
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          789..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          150..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        717..734
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        831..854
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1253 AA;  142840 MW;  C6EFDA8E7F3478AC CRC64;
     MQKGIRLNDG HVASLGLLAR KDGTRKGYLS KRSSDNTKWQ TKWFALLQNL LFYFESDSSS
     RPSGLYLLEG CVCDRAPSPK PALSAKEPLE KQHYFTVNFS HENQKALELR TEDAKDCDEW
     VAAIAHASYR TLATEHEALM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKAEIAS
     LLKDNERIQS TQTVAPNDED SDIKKIKKVQ SFLRGWLCRR KWKTIIQDYI RSPHADSMRK
     RNQVVFSMLE AEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSEHWPQLT
     DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL KHYEAKPDCE ERTLETFLTY
     PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS RIMHDEVSET ENIRKNLAIE
     RMIIEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG SLSLKKEGER QCFLFSKHLI
     ICTRGSGGKL HLTKNGVISL IDCTLLEEPE STEEEAKGSS QDIDHLDFKI GVEPKDSPPF
     TVILVASSRQ EKAAWTSDIS QCVDNIRCNG LMMNAFEENS KVTVPQMIKR TSEGTREAEM
     SRSDASLYCD DVDIRFSKTM NSCKVLQIRY ASVERLLERL TDLRFLSIDF LNTFLHSYRV
     FTTAVVVLDK LITIYKKPIS AIPARWLRSL ELLFASGQNN KLLYGDPPKS PRATRKFSSP
     PPLSITKTSS PSRRRKLSLN IPIITGGKAL DLAALSCNSN GYTSMYSAMS PFSKATLDTS
     KLYVSSSFTN KIPDEGDTTP EKPEDPSVLS KQSSEVSVRE ESDTDQNQSD DGDTETSPTK
     SPTTPKSVKS KNSSEFPLFS YNNGVVMTSC RELDNNRSAL SAASAFAIAT AGANEGTPNK
     EKYRRMSLAS AGFPPDQRNG DKEFVIRRAA TNRVLNVLRH WVSKHSQDFE TNDELKCKVI
     GFLEEVMHDP ELLTQERKAA ANIIRTLTQE DPGDNQITLE EITQMAEGVK AEPFENHSAL
     EIAEQLTLLD HLVFKKIPYE EFFGQGWMKL EKNERTPYIM KTTKHFNDIS NLIASEIIRN
     EDINARVSAI EKWVAVADIC RCLHNYNAVL EITSSMNRSA IFRLKKTWLK VSKQTKALID
     KLQKLVSSEG RFKNLREALK NCDPPCVPYL GMYLTDLAFI EEGTPNYTED GLVNFSKMRM
     ISHIIREIRQ FQQTAYKIEH QAKVTQYLLD QSFVMDEESL YESSLRIEPK LPT
//
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