ID A0A2K6E5X6_MACNE Unreviewed; 384 AA.
AC A0A2K6E5X6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000043566.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000043566.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
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DR AlphaFoldDB; A0A2K6E5X6; -.
DR Ensembl; ENSMNET00000068074.1; ENSMNEP00000043566.1; ENSMNEG00000043296.1.
DR GeneTree; ENSGT00980000198488; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000043296; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR PANTHER; PTHR16675:SF242; CLASS IB MHC ANTIGEN QA-2-RELATED; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022451};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC I {ECO:0000256|ARBA:ARBA00022451};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..384
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014396787"
FT TRANSMEM 308..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 208..297
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 361..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 384 AA; 43297 MW; 934B4596EF687547 CRC64;
MRVMAPRTLL LLLSTALVLT ETWAGSHSLR YFYTAVSRPG RGKPRFILVG YVDDTQFVRF
DSDAESPRME PRAPVMEQEG PEYWEEQTRR AKAHAQTDQV NLRTLLRYYN QSEAGSHTVQ
RMFGCDLGPD GRLLRGYHQS AYDGKDYIAL NEDLRSWTAA DMAAQNTQRK WEAAGVAEQW
RAYLEGTCME WLRRYLENGK ETLQRAEPRK THVTHHPVSD HEATLRCWAL GFYPAEITLT
WQRDGEDQTQ DTELVETRPG GDGTFQKWGA VVVPSGEEQR YTCHVQHQGL REPLTLRWEP
SSQSTIPMVG IVVGLAVLGA VFIIGAVVAA VMWRRKSSCR EGVRGGVRGA ARAGGLEGNG
VGSDLCSERD EESEDSFEQK RAMI
//
