ID   A0A2K6E6C6_MACNE        Unreviewed;      1704 AA.
AC   A0A2K6E6C6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=TSC complex subunit 2 {ECO:0000313|Ensembl:ENSMNEP00000043715.1};
GN   Name=TSC2 {ECO:0000313|Ensembl:ENSMNEP00000043715.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000043715.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000043715.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSMNET00000068223.1; ENSMNEP00000043715.1; ENSMNEG00000044090.1.
DR   GeneTree; ENSGT00950000183139; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000044090; Expressed in cerebellum and 12 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR003913; Tuberin.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   PRINTS; PR01431; TUBERIN.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW   ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          1428..1655
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          618..639
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          893..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          998..1092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1224..1246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1260..1385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1662..1689
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        998..1023
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1267..1291
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1366..1381
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1704 AA;  189299 MW;  ADCDA2B07B567E49 CRC64;
     MAKPTSKDSG LKEKFRILFG LGTPRPNPRS AEGKQTEFII TAEILRELSV ECGLSNRIRM
     IGQICEVAKT KKFEEGERLG VLRALFFKVI KDYPSNEDLH ERLDVFKALT DNGRHITYLE
     EELADFVLQW MDVGLSSEFL LVLVNLVKFN SCYLDEYIAR MVQMICLLCV RTASSVDIEV
     SLQVLDAVVC YNCLPAESLP LFIVTLCRTI NVKELCEPCW KLMRNLLGTH LGHSAIYNMC
     HLMEDRAYME DAPLLRGAVF FVGMALWGAH RLYSLRNSPT SVLPSFYQAM ACPNEVVSYE
     IVLSITRLIK KYRKELQVVT WDILLNIIER LLQQLQTLDS PELRTIVHDL LTTVEELCDQ
     NEFHGSQERY FELVERCADQ RPESSLLNLI SYRAQSIHPA KDGWIQNLQA LMERFFRSES
     RGAVRIKVLD VLSFVLLINR QFYEEELINS VVISQLSHIP EDKDHQVRKL ATQLLVDLAE
     GCHTHHFNSL LDIIEKVMAR SLSPPPELEE RDVAAYSASL EDVKTAVLGL LVILQTKLYT
     LPASHATRVY EMLVSHIQLH YKHSYTLPIA SSIRLQAFDF LLLLRADSLH RLGLPNKDGV
     VRFSPYCVCD YMEPERGSEK KASGPLSPPT GPPGPAPAGP AVRLGSLPYS LLFRVLLQCL
     KQESDWKVLK LVLGRLPESL RYKVLIFTSP CSVDQLCSAL CSMLSGPKTL ERLRGAPEGF
     SRTELHLAVV PVLTALISYH NYLDKTKQRE MVYCLEQGLI HRCASQCVVA LSICSVEMPD
     IMIKALPVLV VKLTHISATA SMAVPLLEFL STLARLPQLY RNFAAEQYAS VFAISLPYTN
     PSKFNQYIVC LAHHVIAMWF IRCRLPFRKD FVPFITKGLR SNVLLSFDDT PEKDSFRARS
     TSLNERPKSR IQTSLTSASL GSADENSVAQ ADDSLKSLHL ELTETCLDMM ARYVFSNFTA
     VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL LGLDSGELQS GPESSSSPGM
     NVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG ALDVPASQFP GSAASPGPQT
     APAAKPEKAS AGTRLPVQEK TNLAAYVPLL TQGWAEILVR RPTGNTSWLM SLENPLSPFS
     SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAST AKPPPLPRSN TDSAVVMEEG
     SPGEVPVPVE PPGLEDFEAA LGVDRRTDAY SRSSSTSSQE EKSFHAEELV AGGIPIERAV
     SSEGGRPSVD LSFQPSQPLS KSSSSPELQT LQDILGDPGD KADVGRLSPE VKARSQSGIL
     DGESAAWPAS GEDSRGQPEG PLPSSSPRSP SGLRPRGYTI SDSAPSRRGR RVERDAFKSR
     ATASNAEKVP GINPSFVFLQ LYHSPFFGDE SNKPILLPNE SQSFERSVQL LDQIPSYDTH
     KIAVLYVGEG QSNSELAILS NEHGSYRYTE FLTGLGRLIE LKDCQPDKVY LGGLDVCGED
     GQFTYCWHDD IMQAVFHIAT LMPTKDVDKH RCDKKRHLGN DFVSIVYNDS GEDFKLGTIK
     GQFNFVHVII TPLDYECNLV SLQCRKDMEG LVDTSVAKIV SDRNLPFVAR QMALHANMAS
     QVHHSRSNPT DIYPSKWIAR LRHIKRLRQR ICEEAAYSNP SLPLVHPPSH TKGPAQTPAE
     PTPGYEMGQR KRLISSVEDF TEFV
//