UniProt: A0A2K6E6T8

Database: UniProt
Entry: A0A2K6E6T8_MACNE

LinkDB:  A0A2K6E6T8_MACNE 
Original site:  A0A2K6E6T8_MACNE

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Ontology (4)   
   GO (4)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (20)   
   InterPro (10)   
   Pfam (5)   
   PROSITE (3)   
   SMART (2)   
All databases (27)   

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ID   A0A2K6E6T8_MACNE        Unreviewed;      1158 AA.
AC   A0A2K6E6T8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Integrin subunit alpha X {ECO:0000313|Ensembl:ENSMNEP00000043874.1};
GN   Name=ITGAX {ECO:0000313|Ensembl:ENSMNEP00000043874.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000043874.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000043874.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR   AlphaFoldDB; A0A2K6E6T8; -.
DR   Ensembl; ENSMNET00000068382.1; ENSMNEP00000043874.1; ENSMNEG00000044550.1.
DR   GeneTree; ENSGT00940000154838; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000044550; Expressed in lung and 7 other cell types or tissues.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR   Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR   Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR   Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR   Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR   Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR048633; ITGAX-like_Ig_3.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR   PANTHER; PTHR23220:SF118; INTEGRIN ALPHA-X; 1.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF20805; Integrin_A_Ig_2; 1.
DR   Pfam; PF00357; Integrin_alpha; 1.
DR   Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR   Pfam; PF00092; VWA; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00191; Int_alpha; 5.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR   SUPFAM; SSF69179; Integrin domains; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51470; FG_GAP; 5.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003762};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003762};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU003762}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   CHAIN           20..1158
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT                   /id="PRO_5014207135"
FT   TRANSMEM        1112..1135
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU003762"
FT   REPEAT          23..78
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   DOMAIN          151..329
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REPEAT          340..391
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          458..518
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          521..577
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT   REPEAT          584..644
FT                   /note="FG-GAP"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ   SEQUENCE   1158 AA;  126160 MW;  E38E1CCC3CE75426 CRC64;
     MTRTRAALLL FTALATSLGF NLDTEELTAF RVDSAGFGDS VVQYANSWVV VGAPQERTAA
     NQTGGLYQCG YSTGACEPTG LQVPPEAVNM SLGLSLAATT SPPQLLACGP TVHHGCGRNM
     YLTGLCFLLA PTQLTRRLPA SGQECPRQEL DIVFLIDGSG SISSGNFAMM MNFVRAVINQ
     FQRPSTQFSL MQFSSKFDIH FTFEEFRRTS NPLDLLASVH QLTGFTHTAT AIQKVVRELF
     QASHGARGDA TKILIVITDG RKEGDSLDYK DVIPMADAAG IIRYAIGVGS AFQNRNSWKE
     LNDIASKPSQ EHIFKVEDFD ALKDIQNQLK EKIFAIEGTE TTSSSSFELE MAQEGFSAVF
     TPDGPILGAV GSFTWSGGAF QYPPNMNPTF INMSQENVDM RDSYLGYSTE LALWKGVQNL
     VLGAPRYQHT GKAAIFTQVS GQWRGFEGLG GEVGPAHRAH DPGSALQIGS YFGASLCSVD
     VDGDGSTDLI LIGAPHYYEQ TRGGQVSVCP LPRGWRKWWC DAVLHGEQGH PWGRFGAALT
     VLGDVNGDKL TDVVIGAPGE EENQGAVYLF HGALGPSIGP SHSQRIAGSQ LSPRLQYFGQ
     ALSGGQDLTQ DGLVDLAVGA RGQALLLRTR PVLWVQVSIQ FKPAEIPRSA FECREQMVSD
     QILGQSSICL YIDKRSKNLL GSRESLPSNP GHPDLWDPPE AEAAWELGRG RGRMRTAGGA
     ERSSTCVEDS VTPITLRLNF TLVGEPLPAF RNLRPMLAAD AQRYFMASLP FEKNCGADHI
     CQDNLGISFS FPGLKTLLVG SNLELNAEVM VWNDGEDSYG TTITFSHPAG LSYRHVAEGQ
     KQGQLRSLRL TCDSAPAGSQ GTWTTSCRIN HLIFRGGAQI TFLATFDVSP KAVLGDRLLL
     TANVSSENNT PRTNKTSFQL ALPLKYAVYT VASSHEQSTK YLNFSDSEEK ESRVAMHRYQ
     VNNLGQRDLP VSINFWVPVE LNQEAVWLEV EVSQPQNPSL RCSSEKIAPP ASDFLAHIQK
     NPVLDCSIAG CLRFCCDIPS FSVQEELDFT LKGNLSFGWV RQTSQKKVSV VSVAEITFDT
     SVYSQLPGQE AFMRAQTTTV LEKYEVHNPT PLIVGSSIGG LLLLALITAA LYKVGFFKRQ
     YKQMMEEANG QIAPENGT
//

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