ID   A0A2K6E766_MACNE        Unreviewed;       908 AA.
AC   A0A2K6E766;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator {ECO:0000313|Ensembl:ENSMNEP00000044002.1};
GN   Name=RALGDS {ECO:0000313|Ensembl:ENSMNEP00000044002.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000044002.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000044002.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_011710050.1; XM_011711748.1.
DR   AlphaFoldDB; A0A2K6E766; -.
DR   Ensembl; ENSMNET00000068510.1; ENSMNEP00000044002.1; ENSMNEG00000044614.1.
DR   GeneID; 105464075; -.
DR   CTD; 5900; -.
DR   GeneTree; ENSGT00940000153181; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000044614; Expressed in cerebellum and 12 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd17209; RA_RalGDS; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR015758; RalGDS_RA.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT   DOMAIN          111..248
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          380..642
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          792..879
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          279..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          722..770
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..297
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        731..770
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   908 AA;  99894 MW;  4889D3C2FC5D9124 CRC64;
     MAREAGQVCA RPAVPRVGKG SVFFACVSVV TARRRAIARR AALQSPTPWL APLPPPATTE
     SSTQEIGEEL INGVIYSISL RKVQLHHGAN KGQRWLGYEN ESALNLYETC KVRTVKAGTL
     EKLVEHLVPA FQGSDLSYVT IFLCTYRAFT TTQQVLDLLF KRYGRCDALT ASSRYGCVLP
     YSDEDGGPQD QLKNAISSIL GTWLDQYSED FCQPPDFPCL KQLVAYVQLN MPGSDLERRA
     HLLLAQLEHS ELTEAEPEAL SPVPALKPTP ELELALTPAR APSPVPAPAP APGSELEVAP
     APAPKLQQAP EPAVELELAP APALELEPAP VPPPEQDPAP SQTLELEPAL VPVPALEPSW
     PSPVVAENGL SEKPHLLVFP PDLVAEQFTL MDAELFKKVV PYHCLGSIWS QRDKKGKEHL
     APTIRATVTQ FNSVANCVIT TCLGDRSTKA PDRARVVEHW IEVARECRIL KNFSSLYAIL
     SALQSNSIHR LKKTWEDVSR DSFRIFQKLS EIFSDENNYS LSRELLIKEG TSKFATLEMN
     PKRAQKRPKE TGIIQGTVPY LGTFLTDLVM LDTAMKDYLY GRLINFEKRR KEFEVIAQIK
     LLQSACNNYS ITPDEQFGVW FRAVERLSET ESYNLSCELE PPSESASNTL RTKKNTAIVK
     RWSDRQAPST ELSTSGSSHS KSCDQLRCGP YLSSGDIADA LSVHSAGSSS SDVEEINISF
     VPESPDGQEK KFWESASQSS PETSGISSAS SSTSSSSAST TPVAATRTHK RSVSGLCNSS
     SALPLYNQQV GDCCIIRVSL DVDNGNMYKS ILVTSQDKAP AVIRKAMDKH NLEEDEPEDY
     ELLQILSDDR KLKIPENANV FYAMNSTANY DFVLKKRAFT KGVKVKHGAS STLPRMKQKG
     LKIAKGIF
//