ID A0A2K6E776_MACNE Unreviewed; 173 AA.
AC A0A2K6E776;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Hes family bHLH transcription factor 2 {ECO:0000313|Ensembl:ENSMNEP00000044015.1};
GN Name=HES2 {ECO:0000313|Ensembl:ENSMNEP00000044015.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000044015.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000044015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_011735928.1; XM_011737626.1.
DR RefSeq; XP_011735936.1; XM_011737634.1.
DR RefSeq; XP_011735945.1; XM_011737643.1.
DR AlphaFoldDB; A0A2K6E776; -.
DR STRING; 9545.ENSMNEP00000044015; -.
DR Ensembl; ENSMNET00000068523.1; ENSMNEP00000044015.1; ENSMNEG00000044620.1.
DR GeneID; 105479604; -.
DR KEGG; mni:105479604; -.
DR CTD; 54626; -.
DR GeneTree; ENSGT00940000161602; -.
DR OMA; NSTGPMW; -.
DR OrthoDB; 2907677at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000044620; Expressed in colon.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11463; bHLH-O_HES2; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF15; TRANSCRIPTION FACTOR HES-2; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 13..70
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 86..119
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 128..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..173
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 173 AA; 18526 MW; C5109D8126A5593E CRC64;
MGLPRRAGDA AELRKSLKPL LEKRRRARIN QSLSQLKGLI LPLLGRENSN CSKLEKADVL
EMTVRFLQEL PALSWPTAAP VPCDSYREGY SACVARLARV LPACRVLEPA VCARLLEHLW
RRAASATLDG GRAGDSGGPS APAPTPASAP QPASVPVPSP PSPPCGPGLW RPW
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