ID A0A2K6E8D3_MACNE Unreviewed; 420 AA.
AC A0A2K6E8D3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=TNF receptor superfamily member 25 {ECO:0000313|Ensembl:ENSMNEP00000044432.1};
GN Name=TNFRSF25 {ECO:0000313|Ensembl:ENSMNEP00000044432.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000044432.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000044432.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR RefSeq; XP_011735846.1; XM_011737544.1.
DR AlphaFoldDB; A0A2K6E8D3; -.
DR STRING; 9545.ENSMNEP00000044432; -.
DR Ensembl; ENSMNET00000068943.1; ENSMNEP00000044432.1; ENSMNEG00000044803.1.
DR GeneID; 105479540; -.
DR KEGG; mni:105479540; -.
DR CTD; 8718; -.
DR GeneTree; ENSGT00940000161888; -.
DR OMA; GVFWVQV; -.
DR OrthoDB; 5343799at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000044803; Expressed in cerebellum and 11 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08815; Death_TNFRSF25_DR3; 1.
DR CDD; cd13420; TNFRSF25; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022329; TNFR_25.
DR InterPro; IPR034050; TNFRSF25_N.
DR PANTHER; PTHR47220; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR PANTHER; PTHR47220:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 25; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 1.
DR PRINTS; PR01972; TNFACTORR25.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..420
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014336201"
FT TRANSMEM 204..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 75..118
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 75..118
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 335..416
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 420 AA; 46076 MW; 26B6D377853CAF56 CRC64;
MEQRSRGSAA VAAVSTALLL VLLGARAQGG TQSPRCDCAG DFHKKNGVFC CRGCPAGHYL
KAPCTEPCGN STCLLCPQDT FLAWENHHNS ECARCQACDE QASQVALENC SAVADTRCGC
KPGWFVECQV SQCVSSSPFY CQPCLDCRAL HRHTRLLCSR RDTDCGTCLP GFYEHDDGCV
SCPTSTLGSC PERCAAVCGW RQMFWVQVLL AGLVVPLLLG ATLTYTYRHC WPHKPMVTAD
EAGMEALTPP PATHLSPSDN AHTLLVPPDS SEKICTVQLV DNNWTPGYPH TQEALCPQMT
WSWDQLPNRA LGPVPASTLL PESPVGSPTM MLQPGPQLYD VMDAVPARRW KEFVRTLGLR
EAEIEAVEVE IGRFRDQQYE MLKRWRQQQP AGLGAVYAAL ERMGLDGCAE DLRSRLQRGP
//
