ID A0A2K6E8L4_MACNE Unreviewed; 979 AA.
AC A0A2K6E8L4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Nidogen 2 {ECO:0000313|Ensembl:ENSMNEP00000044486.1};
GN Name=NID2 {ECO:0000313|Ensembl:ENSMNEP00000044486.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000044486.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000044486.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A2K6E8L4; -.
DR Ensembl; ENSMNET00000068997.1; ENSMNEP00000044486.1; ENSMNEG00000044801.1.
DR GeneTree; ENSGT00940000157901; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000044801; Expressed in lung and 8 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00255; nidG2; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR46513:SF15; NIDOGEN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 2.
DR Pfam; PF06119; NIDO; 1.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 4.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..979
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014321115"
FT DOMAIN 121..351
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 352..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 394..436
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 441..484
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 530..598
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 609..677
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REPEAT 747..790
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 791..833
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 834..878
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 585..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..608
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 567..574
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 647..654
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 979 AA; 107980 MW; F5436F1782C410FD CRC64;
MEGDRVAGRP VLSPLPVLLL LPLLLSRAAA LHPDELFPYG ESWGDQLLQE GDDESSAVVK
LANPLHFYEA RFSNLYVGTN GIISTQDFPR ETQYVDYDFP TDFPAIAPFL ADIDTSHGRG
APHRVNGKVS GHLRVGHTPV HFTDVDLHAY VVGNDGRAYT AISHIPQPAA QALLPLTPIG
GLFGWLFALE KPGSENGFSL AGAAFTHDME VTFYPGEERV HITQTAEGLD PENYLSIKTN
IQGQVPYIPA NFTAHISPYK ELYHYSDSTV TSTSSRDYSL TFGAINQTWS YRIHQNITYQ
VCRHAPRRPA FPTTQQLSVD RVFALYNDEE RVLRFAVTNQ IGPVEEDSDP TPVNPCYDGS
HMCDTTARCH PGTGVDYTCE CASGYQGDGR NCVDENECAT GFHRCGPNSV CINLPGTYRC
ECRSGYEFAD DRHTCILITP PPNPCEDGSH TCAPAGQARC VHHGGSAFSC ACLPGYAGDG
HQCTDIDECS ENRCHPAATC YNTPGSFSCR CQPGYYGDGF QCIPDSTSSL TPCEEQQRHA
QAQYAHPGAR FHIPQCDEQG NFLPLQCHGS TGFCWCVDPD GHEVPGTQTP PGSTPPRCGP
PPEPTQRPPT ICERWRENLL EHYGGTPRDD QYVPQCDDLG HFTPLQCHGK SDFCWCVDKD
GREVQGTRSQ PGTTPACIPT VAPPMVRPTP RPDVTPPSVG TFLLYTQGQQ IGYLPLNGTR
LQKDAAKTLL SLHGSIIVGI DYDCRERMVY WTDVAGRTIS RASLELGAEP ETIVNSGLIS
PEGLAIDHIR RTMYWTDSVM DKIESALLDG SERKVLFHTD LVNPRAIAVD PIRGNLYWTD
WNREAPKIET SSLDGENRRI LINTDIGLPN GLTFDPFSKL LCWADAGTKK LECTLPDGTG
RRVIHNNLKY PFSIVSYADH FYHTDWRRDG VVSVNKHSGQ FTDEYLPEQR SHLYGITAVY
PYCPTGKKYA LGCSCKLAG
//
