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Database: UniProt
Entry: A0A2K6E8T6_MACNE
LinkDB: A0A2K6E8T6_MACNE
Original site: A0A2K6E8T6_MACNE 
ID   A0A2K6E8T6_MACNE        Unreviewed;       740 AA.
AC   A0A2K6E8T6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE   AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN   Name=MTMR12 {ECO:0000313|Ensembl:ENSMNEP00000044598.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000044598.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000044598.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC       {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC       {ECO:0000256|ARBA:ARBA00004369}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; A0A2K6E8T6; -.
DR   Ensembl; ENSMNET00000069109.1; ENSMNEP00000044598.1; ENSMNEG00000044847.1.
DR   GeneTree; ENSGT00940000160263; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000044847; Expressed in cerebellum and 12 other cell types or tissues.
DR   CDD; cd14594; PTP-MTMR12; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR030576; MTMR12_PTP.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT   DOMAIN          198..636
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   740 AA;  85625 MW;  9987145CCB851FA9 CRC64;
     MQSGSAAQAG VQWRDLGSLQ EIHTNEKEVT EKEVTLHLLP GEQLLCEAST VLKYVQEDSC
     QHGVYGRLVC TDFKIAFLGD DESALDNDET QFKNKVVGEN DITLHCVDQI YGVFDEKKKT
     LFGQLKKYPE KLIIHCKDLR VFQFCLRYTK EEEVKRIVSG IIHHTQAPKL LKRLFLFSYA
     TAAQNNTVTD PKNHTIMFDT LKDWCWELER TKGNMKYKAV SVNEGYKVCE RLPAYFVVPT
     PLPEENVHRF QGHGIPIWCW SCHNGSALLK MSALPKEQDD GILQIQKSFL DGVYKTIHRP
     PYEIVKTEDL SSNFLSLQEI QTAYSKFKQL FLIDNSTEFW DTDIKWFSLL ESSSWLDIIR
     RCLKKAIEIT ECMEAQNMNV LLLEENASDL CCLISSLVQL MMDPHCRTRI GFQSLIQKEW
     VMGGHCFLDR CNHLRQNDKE EVPVFLLFLD CVWQLVHQHP PAFEFTETYL TVLSDSLYIP
     IFSTFFFNSP HQKDTNMGRE GQDTQSKPLN LLTVWDWSVQ FEPKAQTLLK NPLYVEKPKL
     DKGQRKGMRF KHQRQLSLPL TQSKSSPKRG FFREETDHLI KNLLGKRISK LINSSDELQD
     NFREFYDSWH SKPTDYHGLL LPHIEGPEIK VWAQRYLRWI PEAQILGGSR VATMSKLLEM
     IEEVQSLQEK IDERHHSQQA PQAEAPCLLR NSARLSSLFP FALLQRHSSK PVLPTSGWKA
     LGDEDDLAKR EDEFVDLGDV
//
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