ID   A0A2K6E927_MACNE        Unreviewed;       247 AA.
AC   A0A2K6E927;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Stanniocalcin-1 {ECO:0000256|RuleBase:RU369112};
DE            Short=STC-1 {ECO:0000256|RuleBase:RU369112};
GN   Name=STC1 {ECO:0000313|Ensembl:ENSMNEP00000044670.1};
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000044670.1, ECO:0000313|Proteomes:UP000233120};
RN   [1] {ECO:0000313|Ensembl:ENSMNEP00000044670.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Stimulates renal phosphate reabsorption, and could therefore
CC       prevent hypercalcemia. {ECO:0000256|RuleBase:RU369112}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|ARBA:ARBA00011748,
CC       ECO:0000256|RuleBase:RU369112}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU369112}.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family.
CC       {ECO:0000256|ARBA:ARBA00008693, ECO:0000256|RuleBase:RU369112}.
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DR   RefSeq; XP_011740221.1; XM_011741919.1.
DR   AlphaFoldDB; A0A2K6E927; -.
DR   SMR; A0A2K6E927; -.
DR   STRING; 9545.ENSMNEP00000044670; -.
DR   Ensembl; ENSMNET00000069181.1; ENSMNEP00000044670.1; ENSMNEG00000044899.1.
DR   GeneID; 105482049; -.
DR   KEGG; mni:105482049; -.
DR   CTD; 6781; -.
DR   GeneTree; ENSGT00390000005989; -.
DR   OMA; CAERTMP; -.
DR   OrthoDB; 4573585at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000044899; Expressed in adult mammalian kidney and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0035988; P:chondrocyte proliferation; IEA:Ensembl.
DR   GO; GO:0001886; P:endothelial cell morphogenesis; IEA:Ensembl.
DR   GO; GO:0003421; P:growth plate cartilage axis specification; IEA:Ensembl.
DR   GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
DR   GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR   GO; GO:1903403; P:negative regulation of renal phosphate excretion; IEA:Ensembl.
DR   GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR   GO; GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl.
DR   GO; GO:0044070; P:regulation of monoatomic anion transport; IEA:Ensembl.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; STANNIOCALCIN; 1.
DR   PANTHER; PTHR11245:SF1; STANNIOCALCIN-1; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|RuleBase:RU369112};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hormone {ECO:0000256|ARBA:ARBA00022702};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369112};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..247
FT                   /note="Stanniocalcin-1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014472779"
SQ   SEQUENCE   247 AA;  27612 MW;  1E4A8BCF51B49AED CRC64;
     MLQNSAVLLV LVISASATHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL QVGCGAFACL
     ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGVTSKVFLA IRRCSTFQRM
     IAEVQEECYS KLNVCSIAKR NPEAITEVVQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD
     SLMEKIGPNM ASLFHILQTD HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEEDSPSHIK
     RTSQESA
//