ID A0A2K6EAA3_MACNE Unreviewed; 730 AA.
AC A0A2K6EAA3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Metastasis associated 1 {ECO:0000313|Ensembl:ENSMNEP00000045101.1};
GN Name=MTA1 {ECO:0000313|Ensembl:ENSMNEP00000045101.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000045101.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000045101.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011753360.1; XM_011755058.1.
DR AlphaFoldDB; A0A2K6EAA3; -.
DR STRING; 9545.ENSMNEP00000045101; -.
DR Ensembl; ENSMNET00000069612.1; ENSMNEP00000045101.1; ENSMNEG00000044997.1.
DR GeneID; 105489864; -.
DR KEGG; mni:105489864; -.
DR CTD; 9112; -.
DR GeneTree; ENSGT01030000234573; -.
DR OrthoDB; 12566at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000044997; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016581; C:NuRD complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:Ensembl.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEA:Ensembl.
DR GO; GO:0045475; P:locomotor rhythm; IEA:Ensembl.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IEA:Ensembl.
DR GO; GO:1902499; P:positive regulation of protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
DR CDD; cd04709; BAH_MTA; 1.
DR CDD; cd11661; SANT_MTA3_like; 1.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 4.10.1240.50; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR040138; MIER/MTA.
DR InterPro; IPR035170; MTA1_R1.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR10865; METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN; 1.
DR PANTHER; PTHR10865:SF5; METASTASIS-ASSOCIATED PROTEIN MTA1; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00320; GATA; 1.
DR Pfam; PF17226; MTA_R1; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 15..175
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 176..287
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 294..346
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 446..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 82051 MW; 4D3FC133DD9E2B8E CRC64;
MPCGLGGEGQ GHTLPGVGGK DYVYFENSSS NPYLIRRIEE LNKTANGNVE AKVVCFYRRR
DISSTLIALA DKHATLSVCY KAGPGADNGE EGEIEEEMEN PEMVDLPEKL KHQLRHRELF
LSRQLESLPA THIRGKCSVT LLNETESLKS YLEREDFFFY SLVYDPQQKT LLADKGEIRV
GNRYQADITD LLKEGEEDGR DQSKLETKVW EAHNPLTDKQ IDQFLVVARS VGTFARALDC
SSSVRQPSLH MSAAAASRDI TLFHAMDTLH KNIYDISKAI SALVPQGGPV LCRDEMEEWS
ASEANLFEEA LEKYGKDFTD IQQDFLPWKS LTSIIEYYYM WKTTDRYVQQ KRLKAAEAES
KLKQVYIPNY NKPNPNQISV NNVKAGVVNG TGAPGQSPGA GRACESCYTT QSYQWYSWGP
PNMQCRLCAS CWTYWKKYGG LKMPTRLDGE RPGPNRSNMS PHGLPARSSG SPKFAMKTRQ
AFYLHTTKLT RIARRLCREI LRPWHAARHP YLPINSAAIK AECTARLPEA SQSPLVLKQA
VRKPLEAVLR YLETHPRPPK PDPVKSVSSV LSSLTPAKAA PVINNGSPTI LGKRSYEQHN
GVDGNMKKRL LMPSRGTYLG LANHGQTRHM GPSRNLLLNG KSYPTKVRLI RGGSLPPVKR
RRMNWIDAPD DVFYMATEET RKIRKLLSSS ETKRAARRPY KPIALRQSQA LPLRPPPPAP
VNDEPIVIED
//
