ID A0A2K6ECF5_MACNE Unreviewed; 700 AA.
AC A0A2K6ECF5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 {ECO:0000313|Ensembl:ENSMNEP00000045849.1};
GN Name=HPS1 {ECO:0000313|Ensembl:ENSMNEP00000045849.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000045849.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000045849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011734007.1; XM_011735705.1.
DR RefSeq; XP_011734008.1; XM_011735706.1.
DR RefSeq; XP_011734009.1; XM_011735707.1.
DR RefSeq; XP_011734010.1; XM_011735708.1.
DR RefSeq; XP_011734011.1; XM_011735709.1.
DR RefSeq; XP_011734012.1; XM_011735710.1.
DR AlphaFoldDB; A0A2K6ECF5; -.
DR STRING; 9545.ENSMNEP00000045849; -.
DR Ensembl; ENSMNET00000070362.1; ENSMNEP00000045849.1; ENSMNEG00000045397.1.
DR GeneID; 105478428; -.
DR KEGG; mni:105478428; -.
DR CTD; 3257; -.
DR GeneTree; ENSGT00390000015298; -.
DR OrthoDB; 3671710at2759; -.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000045397; Expressed in lymph node and 12 other cell types or tissues.
DR GO; GO:0031085; C:BLOC-3 complex; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:Ensembl.
DR GO; GO:1903232; P:melanosome assembly; IEA:Ensembl.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR043972; FUZ/MON1/HPS1_longin_1.
DR InterPro; IPR043971; FUZ/MON1/HPS1_longin_2.
DR InterPro; IPR043970; FUZ/MON1/HPS1_longin_3.
DR InterPro; IPR026053; HPS1.
DR PANTHER; PTHR12761:SF1; HERMANSKY-PUDLAK SYNDROME 1 PROTEIN; 1.
DR PANTHER; PTHR12761; HERMANSKY-PUDLAK SYNDROME PROTEIN 1; 1.
DR Pfam; PF19036; Fuz_longin_1; 1.
DR Pfam; PF19037; Fuz_longin_2; 1.
DR Pfam; PF19038; Fuz_longin_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 2..159
FT /note="FUZ/MON1/HPS1 first Longin"
FT /evidence="ECO:0000259|Pfam:PF19036"
FT DOMAIN 205..403
FT /note="FUZ/MON1/HPS1 second Longin"
FT /evidence="ECO:0000259|Pfam:PF19037"
FT DOMAIN 540..694
FT /note="FUZ/MON1/HPS1 third Longin"
FT /evidence="ECO:0000259|Pfam:PF19038"
FT REGION 249..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 79185 MW; 04A0C46AB5966732 CRC64;
MKCVLVATEG AEVLFYWTDD EFEESLRLKF GQSENEEEEL PALEDQLSTL LAPVIISSMT
MLEKLSDTYT CFSTENGNSL YVLHLFGECL FIAINGDHTE SEGDLRRKLY VLKYLFEVHF
GLVTVDGQLI RKELRPPDLG QRVQLWEHFQ SLLWTYSRLR EQEQCFAVEA LERLIHPQLC
ELCIEALERH VIQAVNTSSE RGGEEALHAF LLVHSKLLAF YSSHSASSLR PADLLILILL
VQDLYPSEST VEDDTQPSPR RARSSQNIPV QQAWSPHSTG PTRGSSAETE TDSFSLPEEY
FTPAPSPGDQ SSGSTIWLEG GTPPMEALQI AEDTLQTLVP HCPAPSSPRR IFLDANVKES
YCPLVPHTMY CLPLWPGINL VLLTRSPSAP LALVLSQLMD GFAMLEKKLK EGPEAGASLR
SQPLVGDLRQ RMDKFVKNRG AQEIQSTWLE FKAKAFSKSE PGSSSELLQA CGKLKRQLCA
IYRLNFLTTA PNRGGPHLPQ HLQDQVQRLM REKLTDWKDF LLVKSRRNIT MVSYLEDFPG
LVHFIYVDRT TGQMVAPSLN CSEKTSSELG KGPLAAFVKT KVWSLIQLAR RYLQKGYTTL
LFQEGDFYCS YFLWFENDMG YKLQMIEVPV LSDDSVPIGM LGGDYYRKLL RYYSKNRPAE
AVRCYELLAL HLSVIPTDLL VQQAGQLARR LWEASRIPLL
//
