ID A0A2K6ECK0_MACNE Unreviewed; 173 AA.
AC A0A2K6ECK0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase {ECO:0000256|ARBA:ARBA00012257};
DE EC=4.1.1.97 {ECO:0000256|ARBA:ARBA00012257};
DE AltName: Full=Parahox neighbor {ECO:0000256|ARBA:ARBA00032116};
DE AltName: Full=Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase {ECO:0000256|ARBA:ARBA00030624};
GN Name=URAD {ECO:0000313|Ensembl:ENSMNEP00000045886.1};
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000045886.1, ECO:0000313|Proteomes:UP000233120};
RN [1] {ECO:0000313|Ensembl:ENSMNEP00000045886.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the stereoselective decarboxylation of 2-oxo-4-
CC hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
CC {ECO:0000256|ARBA:ARBA00002506}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-
CC carboxylate + H(+) = (S)-allantoin + CO2; Xref=Rhea:RHEA:26301,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:58639; EC=4.1.1.97;
CC Evidence={ECO:0000256|ARBA:ARBA00001163};
CC -!- PATHWAY: Purine metabolism; urate degradation; (S)-allantoin from
CC urate: step 3/3. {ECO:0000256|ARBA:ARBA00004754}.
CC -!- SIMILARITY: Belongs to the OHCU decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00005793}.
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DR RefSeq; XP_011753904.1; XM_011755602.1.
DR AlphaFoldDB; A0A2K6ECK0; -.
DR STRING; 9545.ENSMNEP00000045886; -.
DR Ensembl; ENSMNET00000070399.1; ENSMNEP00000045886.1; ENSMNEG00000045421.1.
DR GeneID; 105490200; -.
DR CTD; 646625; -.
DR GeneTree; ENSGT00940000153229; -.
DR OMA; RCQNERA; -.
DR OrthoDB; 2903165at2759; -.
DR UniPathway; UPA00394; UER00652.
DR Proteomes; UP000233120; Unplaced.
DR Bgee; ENSMNEG00000045421; Expressed in liver.
DR GO; GO:0051997; F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0000255; P:allantoin metabolic process; IEA:InterPro.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.3330.10; Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 1.
DR InterPro; IPR018020; OHCU_decarboxylase.
DR InterPro; IPR017580; OHCU_decarboxylase-1.
DR InterPro; IPR036778; OHCU_decarboxylase_sf.
DR NCBIfam; TIGR03164; UHCUDC; 1.
DR PANTHER; PTHR43466; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR43466:SF1; 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED; 1.
DR Pfam; PF09349; OHCU_decarbox; 1.
DR SUPFAM; SSF158694; UraD-Like; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Purine metabolism {ECO:0000256|ARBA:ARBA00022631};
KW Reference proteome {ECO:0000313|Proteomes:UP000233120}.
FT DOMAIN 7..163
FT /note="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline
FT decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF09349"
SQ SEQUENCE 173 AA; 19176 MW; 50607E412DEB68F9 CRC64;
MDIEKVNSMD FGEFVDVFGN VIERCPLIAA AVWSQRPFSD LEDLKKHFFA FIDALPQSGQ
EGILRCHPDL AGSELRRGTL TAESQREQSA AGLTSLGADE RLRLAELNAQ YRARFGFPFV
LAARFSDRAA VSRELARRLL CPSAQELRTA LGEVKKIGSL RLADLLRADP AKL
//
