ID A0A2K6EEJ3_PROCO Unreviewed; 316 AA.
AC A0A2K6EEJ3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Cathepsin O {ECO:0000313|Ensembl:ENSPCOP00000000154.1};
GN Name=CTSO {ECO:0000313|Ensembl:ENSPCOP00000000154.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000000154.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000000154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR RefSeq; XP_012500709.1; XM_012645255.1.
DR AlphaFoldDB; A0A2K6EEJ3; -.
DR STRING; 379532.ENSPCOP00000000154; -.
DR Ensembl; ENSPCOT00000000409.1; ENSPCOP00000000154.1; ENSPCOG00000000380.1.
DR GeneID; 105811126; -.
DR KEGG; pcoq:105811126; -.
DR CTD; 1519; -.
DR GeneTree; ENSGT00940000159253; -.
DR OMA; FPHENST; -.
DR OrthoDB; 5472948at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR PANTHER; PTHR12411:SF947; CATHEPSIN O; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..316
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018531203"
FT DOMAIN 103..315
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 316 AA; 35180 MW; 008CA7003B876E2A CRC64;
MELRWLLWLL CCGGGGGTGS GATFTPTWPR SREREAAAFR ESLNRHRYLN SLFPSENSTA
FYGINQFSYL FPEEFKAIYL RSRPSRFPRY SAGVQMSISN VSLPLRFDWR DKHVVTQVRN
QQTCGGCWAF SVVGAVESAC AIKGEALEDL SVQQVIDCSY NNYGCNGGST LNALNWLNKM
QVKLVRDSEY PFKAQNGLCH YFSGSHFGFS IKGYYAYDFS EQEDEMVKAL LTFGPLVVIV
DAVSWQDYLG GIIQHHCSSG EANHAVLITG FDKTGSTPYW IVRNSWGSSW GVDGYAHVKM
GSNVCGIADS VSAIFV
//
