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Database: UniProt
Entry: A0A2K6EFG8_PROCO
LinkDB: A0A2K6EFG8_PROCO
Original site: A0A2K6EFG8_PROCO 
ID   A0A2K6EFG8_PROCO        Unreviewed;       480 AA.
AC   A0A2K6EFG8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=Iroquois homeobox 1 {ECO:0000313|Ensembl:ENSPCOP00000000479.1};
GN   Name=IRX1 {ECO:0000313|Ensembl:ENSPCOP00000000479.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000000479.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000000479.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family.
CC       {ECO:0000256|ARBA:ARBA00008446}.
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DR   RefSeq; XP_012519183.1; XM_012663729.1.
DR   AlphaFoldDB; A0A2K6EFG8; -.
DR   STRING; 379532.ENSPCOP00000000479; -.
DR   Ensembl; ENSPCOT00000001503.1; ENSPCOP00000000479.1; ENSPCOG00000001340.1.
DR   GeneID; 105825826; -.
DR   KEGG; pcoq:105825826; -.
DR   CTD; 79192; -.
DR   GeneTree; ENSGT00940000160429; -.
DR   OMA; FRPIQDR; -.
DR   OrthoDB; 2915644at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR003893; Iroquois_homeo.
DR   PANTHER; PTHR11211; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX; 1.
DR   PANTHER; PTHR11211:SF13; IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-1; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00548; IRO; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          135..188
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        137..189
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          190..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        190..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..228
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        403..417
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   480 AA;  49840 MW;  1CF37386DDAA7D3D CRC64;
     MSFPQLGYPQ YLSAAGPGAY GSERPGVLAA AAAAAAAASS GRPGAAELGA GAGAAAVTSV
     LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY
     GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN
     ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ
     SNEDDEDKAE APHAPATPTA LTRDQGSPLA ATDVLKPQDS PLGLAKEVPE PGSTRLLSPG
     AAAGGLQGAP HSKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGT PLQHPAFLPS
     HGLYTCHIGK FSNWTNGAFL AQGSLLNMRS FLGVGAPHAA PHGQHLPAPP PPQPPVAVAA
     GVLHGDKASV RNSPTLPERD LVPRPDSPAQ QSKSPFQPVR DNSLAPQEGA PRILAALPSA
//
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