ID A0A2K6EG59_PROCO Unreviewed; 95 AA.
AC A0A2K6EG59;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Pancreatic polypeptide {ECO:0000313|Ensembl:ENSPCOP00000000713.1};
GN Name=PPY {ECO:0000313|Ensembl:ENSPCOP00000000713.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000000713.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000000713.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Hormone secreted by pancreatic cells that acts as a regulator
CC of pancreatic and gastrointestinal functions probably by signaling
CC through the G protein-coupled receptor NPY4R2.
CC {ECO:0000256|ARBA:ARBA00037168}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the NPY family. {ECO:0000256|ARBA:ARBA00010022,
CC ECO:0000256|RuleBase:RU000656}.
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DR AlphaFoldDB; A0A2K6EG59; -.
DR STRING; 379532.ENSPCOP00000000713; -.
DR Ensembl; ENSPCOT00000002549.1; ENSPCOP00000000713.1; ENSPCOG00000002280.1.
DR GeneTree; ENSGT00530000064295; -.
DR OMA; MAATRRC; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00126; PAH; 1.
DR Gene3D; 6.10.250.900; -; 1.
DR InterPro; IPR001955; Pancreatic_hormone-like.
DR InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR PANTHER; PTHR10533; NEUROPEPTIDE Y/PANCREATIC HORMONE/PEPTIDE YY; 1.
DR PANTHER; PTHR10533:SF2; PANCREATIC PROHORMONE; 1.
DR Pfam; PF00159; Hormone_3; 1.
DR PRINTS; PR00278; PANCHORMONE.
DR SMART; SM00309; PAH; 1.
DR PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..95
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014356403"
FT REGION 64..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 95 AA; 10538 MW; BF50F250F11282CF CRC64;
MAATRRCLSL LLLSTCVALL LQPPLGAQGA PMEPVYPGDD ATPEQMAQYV ADLRRYINML
TRPRYGKRDK EDAPDSLQWD SPHAAAPREL SPMDL
//
