ID A0A2K6EH56_PROCO Unreviewed; 311 AA.
AC A0A2K6EH56;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Purine rich element binding protein B {ECO:0000313|Ensembl:ENSPCOP00000001066.1};
GN Name=PURB {ECO:0000313|Ensembl:ENSPCOP00000001066.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000001066.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000001066.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PUR DNA-binding protein family.
CC {ECO:0000256|ARBA:ARBA00009251}.
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DR RefSeq; XP_012502430.1; XM_012646976.1.
DR AlphaFoldDB; A0A2K6EH56; -.
DR STRING; 379532.ENSPCOP00000001066; -.
DR Ensembl; ENSPCOT00000003821.1; ENSPCOP00000001066.1; ENSPCOG00000003416.1.
DR GeneID; 105812500; -.
DR KEGG; pcoq:105812500; -.
DR CTD; 5814; -.
DR GeneTree; ENSGT00950000183162; -.
DR OMA; FQPAPRG; -.
DR OrthoDB; 1040548at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IEA:Ensembl.
DR GO; GO:0032422; F:purine-rich negative regulatory element binding; IEA:InterPro.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0046332; F:SMAD binding; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 3.10.450.700; -; 1.
DR Gene3D; 3.30.2450.30; -; 1.
DR InterPro; IPR006628; PUR-bd_fam.
DR PANTHER; PTHR12611; PUR-TRANSCRIPTIONAL ACTIVATOR; 1.
DR PANTHER; PTHR12611:SF4; TRANSCRIPTIONAL ACTIVATOR PROTEIN PUR-BETA; 1.
DR Pfam; PF04845; PurA; 1.
DR SMART; SM00712; PUR; 3.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 311 AA; 33138 MW; FE4356CD9FE8E60C CRC64;
MADGDSGSER GGGGPGGFQP ASRGGGEQET QELASKRLDI QNKRFYLDVK QNAKGRFLKI
AEVGAGGSKS RLTLSMAVAA EFRDSLGDFI EHYAQLGPSS PEQLAAGAEE GGGPRRALKS
EFLVRENRKY YLDLKENQRG RFLRIRQTVN RGGGGFGAGP GPGGLQSGQT IALPAQGLIE
FRDALAKLID DYGGEDDELA GGPGGGAGGP GGGLYGELPE GTSITVDSKR FFFDVGCNKY
GVFLRVSEVK PSYRNAITVP FKAWGKFGGA FCRYADEMKE IQERQRDKLY ERRGGGSGGG
EESEGEEVDE D
//
