ID   A0A2K6EHL8_PROCO        Unreviewed;       689 AA.
AC   A0A2K6EHL8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN   Name=NCSTN {ECO:0000313|Ensembl:ENSPCOP00000001233.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000001233.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000001233.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the nicastrin family.
CC       {ECO:0000256|ARBA:ARBA00007717}.
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DR   AlphaFoldDB; A0A2K6EHL8; -.
DR   Ensembl; ENSPCOT00000004375.1; ENSPCOP00000001233.1; ENSPCOG00000003818.1.
DR   GeneTree; ENSGT00390000014633; -.
DR   OMA; ECVYPGV; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016485; P:protein processing; IEA:InterPro.
DR   CDD; cd03881; M28_Nicastrin; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR041084; Ncstrn_small.
DR   InterPro; IPR008710; Nicastrin.
DR   PANTHER; PTHR21092; NICASTRIN; 1.
DR   PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR   Pfam; PF18266; Ncstrn_small; 1.
DR   Pfam; PF05450; Nicastrin; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        650..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..203
FT                   /note="Nicastrin small lobe"
FT                   /evidence="ECO:0000259|Pfam:PF18266"
SQ   SEQUENCE   689 AA;  76622 MW;  3FEBE1639443B364 CRC64;
     MDMSSILESL CRGNSVERKI YIPLNKTAPC VRLLNATHQI GCQSSISGDT GVIHVVEKEE
     DLQWVLTDGP NPPYMVLLEG NLFTRDLMEK LKGRTSRIAG LAVSLSKPSP ASGFSPSVQC
     PNDGFGVYSN SYGPEFAHCG EIQWNSLGSG LAYEDFSFPI FLLEDENETR VIKQCYQDHN
     LSQNGSAPTF PLCAMQLFSH MHAVISTATC MRRSSIQNTF SINPEIVCDP LSDYNVWSML
     KPINTSGTLK SADRVVVAAT RLDSRSFFWN VAPGAESAVA SFVTQLAAAE ALQKAPDVST
     LPHNVMFVFF QGETFDYIGS SRMVYDMEKG KFPVQLENID SFVELGQVAL RTSLELWMHT
     DPMSQKNESV RSQVEDLLAT LEKSGAGVPA VVLRRPNQSQ PLPPSSLQRF LRARNISGVV
     LADHSTAFHN KYYQSIYDTA ENINVSYPEW LSPEEDLNFV TDTAKALADV ATVLGRALYE
     LAGGTNFSDT IQADPQTVTR LLYGFLVRAN NSWFQSILRQ DLRSYLGDGP LQHYIAVSSP
     TNTTYVVQYA LANLTGEVIN LTREQCQDPS KVPNENKDLY EYSWVQGPLN SNETDRLPRC
     VRSTARLARA LSPAFELSQW SSTEYSTWTE SRWKDIRARI FLIASKELEF ITLMVGFGIL
     IFSLVVTYCI NAKADVLFIV PREPGAVSY
//