ID   A0A2K6EJ24_PROCO        Unreviewed;       341 AA.
AC   A0A2K6EJ24;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=LIM and senescent cell antigen-like-containing domain protein {ECO:0000256|PIRNR:PIRNR038003};
GN   Name=LIMS2 {ECO:0000313|Ensembl:ENSPCOP00000001733.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000001733.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000001733.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Adapter protein in a cytoplasmic complex linking beta-
CC       integrins to the actin cytoskeleton, bridges the complex to cell
CC       surface receptor tyrosine kinases and growth factor receptors.
CC       {ECO:0000256|PIRNR:PIRNR038003}.
CC   -!- SUBUNIT: Part of the heterotrimeric IPP complex composed of integrin-
CC       linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
CC       {ECO:0000256|PIRNR:PIRNR038003}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC       {ECO:0000256|PIRNR:PIRNR038003}. Cell membrane
CC       {ECO:0000256|PIRNR:PIRNR038003}; Peripheral membrane protein
CC       {ECO:0000256|PIRNR:PIRNR038003}.
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DR   RefSeq; XP_012505397.1; XM_012649943.1.
DR   AlphaFoldDB; A0A2K6EJ24; -.
DR   Ensembl; ENSPCOT00000006116.1; ENSPCOP00000001733.1; ENSPCOG00000005424.1.
DR   GeneID; 105814837; -.
DR   KEGG; pcoq:105814837; -.
DR   CTD; 55679; -.
DR   GeneTree; ENSGT00940000153518; -.
DR   OrthoDB; 370973at2759; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd09331; LIM1_PINCH; 1.
DR   CDD; cd09332; LIM2_PINCH; 1.
DR   CDD; cd09333; LIM3_PINCH; 1.
DR   CDD; cd09334; LIM4_PINCH; 1.
DR   CDD; cd09335; LIM5_PINCH; 1.
DR   Gene3D; 2.10.110.10; Cysteine Rich Protein; 5.
DR   InterPro; IPR047944; LIMS1/2-like_LIM1.
DR   InterPro; IPR047946; PINCH-1/2-like.
DR   InterPro; IPR001781; Znf_LIM.
DR   PANTHER; PTHR24210:SF10; LIM AND SENESCENT CELL ANTIGEN-LIKE-CONTAINING DOMAIN PROTEIN 2; 1.
DR   PANTHER; PTHR24210; LIM DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00412; LIM; 5.
DR   PIRSF; PIRSF038003; PINCH; 1.
DR   SMART; SM00132; LIM; 5.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 6.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 4.
PE   4: Predicted;
KW   Cell junction {ECO:0000256|PIRNR:PIRNR038003};
KW   Cell membrane {ECO:0000256|PIRNR:PIRNR038003};
KW   LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PIRNR:PIRNR038003};
KW   Membrane {ECO:0000256|PIRNR:PIRNR038003};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT   DOMAIN          13..74
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
FT   DOMAIN          76..133
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
FT   DOMAIN          196..255
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
FT   DOMAIN          256..315
FT                   /note="LIM zinc-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50023"
SQ   SEQUENCE   341 AA;  38910 MW;  618855FB4C4C0981 CRC64;
     MTGSNMSDAL ANAVCQRCQA RFAPAERIVH SSGELYHEHC FVCAQCFRPF PEGLFYEFEG
     RKYCEHDFQM LFAPCCGSCG EFIIGRVIKA MNNNWHPGCF RCELCDVELA DLGFVKNAGR
     HLCRPCHNRE KAKGLGKYIC QRCHLVIDEQ PLMFRNDAYH PDHFSCTHCG KELTAEAREL
     KGELYCLPCH DKMGVPICGA CRRPIEGRVV NALGKQWHVE HFVCAKCEKP FLGHRHYEKK
     GLAYCETHYN QLFGDVCYNC SHVIEGDVVS ALNKAWCVSC FSCSTCNSKL TLKNKFVEFD
     MKPVCKRCYE KFPLELKKRL KKLSELTSRK AQPKSVDLNS A
//