ID A0A2K6EKE3_PROCO Unreviewed; 1635 AA.
AC A0A2K6EKE3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Neurexin 2 {ECO:0000313|Ensembl:ENSPCOP00000002206.1};
GN Name=NRXN2 {ECO:0000313|Ensembl:ENSPCOP00000002206.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000002206.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000002206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPCOT00000007652.1; ENSPCOP00000002206.1; ENSPCOG00000006501.1.
DR GeneTree; ENSGT00940000155978; -.
DR OMA; XHAGIGH; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1635
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014457591"
FT TRANSMEM 1561..1581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..206
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 202..242
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 263..448
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 455..648
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 652..689
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 694..857
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 871..1046
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1049..1086
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1090..1268
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1381..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1448..1549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1602..1635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1498..1524
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1619..1635
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1635 AA; 176345 MW; 44C1B64853FACC83 CRC64;
MAPGSRWRPP PPLLLLLLLL ALVAGADGLE FGGGPGQWAR YARWAGAASS GELSFSLRTN
ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD
ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA
NLKLGERPPA LLGSQGLRGA AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF
CSEGEPRGPA HLTLNSEGKE EFVATFKGNE FFCYDLSHNP IQSSTDEITL AFRTLQRNGL
MLHTGKSADY VNLSLKSGAV WLVINLGSGA FEALVEPVNG KFNDNAWHDV RVTRNLRQVG
GVTISVDGIL TTTGYTQEDY TMLGSDDFFY IGGSPNTADL PGSPVSNNFM GCLKDVVYKN
NDFKLELSRL AKEGDPKMKL QGDLSFRCED VAALDPVTFE SPEAFVALPR WSAKRTGSIS
LDFRTTEPNG LLLFSQGRRA GAGAGGHSST QRADYFAMEL LDGYLYLLLD MGSGGIKLRA
SSRKVNDGEW CHVDFQRDGR KGSISVNSRS TPFLATGESE ILDLESELYL GGLPEGGRVD
LPLPPEVWTA ALRAGYVGCV RDLFIDGRSR DLRGLAETQG AVGVAPFCSR ETLKQCASGP
CRNGGVCREG WNRFVCDCIG TGFLGRVCER EATVLSYDGS MYMKIMLPNA MHTEAEDVSL
RFMSQRAYGL MMATTSRESA DTLRLELDGG QMKLTVNLGK GPETLFAGHK LNDNEWHTVR
VVRRGKSLQL SVDNVTVEGQ MAGAHTRLEF HNIETGIMTE RRFISVVPSN FIGHLSGLVF
NGQPYMDQCK DGDITYCELN ARFGLRAIVA DPVTFKSRSS YLALATLQAY ASMHLFFQFK
TTAPDGLLLF NSGNGNDFIV IELVKGYIHY VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS
RDPGNVHTLK IDSRTVTQHS NGARNLDLKG ELYIGGLSKN MFSNLPKLVA SRDGFQGCLA
SVDLNGRLPD LIADALHRIG QVERGCDGPS TTCTEESCAN QGVCLQQWDG FTCDCTMTSY
GGPVCNDPGT TYIFGKGGAL ITYTWPPNDR PSTRMDRLAV GFSTHQRSAV LVRVDSASGL
GDYLQLHIEQ GTVGVIFNVG TDDITIDEPN AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN
ERYPAGRQLT IFNSQAAIKI GGRDQGRPFQ GQVSGLYYNG LKVLALAAES DPNVRTEGHL
RLVGEGPSVL LSAETTATTL LADMATTIME TTTTMATTTT RRGRSPTLRD STTQNTDDLL
VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP TFYPFLTGVG
ATQDTLPPPA ARRPPSGGPC QAERDDSDCE EPIEASGFAS GEVFDSSLPP TDDEDFYTTF
PLVTDRTTLL SPRKPAPRPN LRTDGATGAP GVLLAPSAPA PNLPAGKMNH RDPLQPLLEN
PPLGPGAPTS FEPRRPPPLR PGVTSAPGFP HLPTANPTGP GERGPPGAVE VIRESSSTTG
MVVGIVAAAA LCILILLYAM YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV VKEKAPAAPK
TPSKAKKNKD KEYYV
//
