ID   A0A2K6EKV8_PROCO        Unreviewed;       507 AA.
AC   A0A2K6EKV8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Centromere protein T {ECO:0000256|ARBA:ARBA00016401};
GN   Name=CENPT {ECO:0000313|Ensembl:ENSPCOP00000002363.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000002363.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000002363.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CENP-T/CNN1 family.
CC       {ECO:0000256|ARBA:ARBA00010137}.
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DR   AlphaFoldDB; A0A2K6EKV8; -.
DR   STRING; 379532.ENSPCOP00000002363; -.
DR   Ensembl; ENSPCOT00000008186.1; ENSPCOP00000002363.1; ENSPCOG00000007216.1.
DR   GeneTree; ENSGT00390000003044; -.
DR   OMA; YFQHLCN; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0000939; C:inner kinetochore; IEA:Ensembl.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:Ensembl.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR028255; CENP-T.
DR   InterPro; IPR035425; CENP-T/H4_C.
DR   InterPro; IPR032373; CENP-T_N.
DR   InterPro; IPR009072; Histone-fold.
DR   PANTHER; PTHR46904; CENTROMERE PROTEIN T; 1.
DR   PANTHER; PTHR46904:SF1; CENTROMERE PROTEIN T; 1.
DR   Pfam; PF15511; CENP-T_C; 1.
DR   Pfam; PF16171; CENP-T_N; 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Centromere {ECO:0000256|ARBA:ARBA00023328};
KW   Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW   Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT   DOMAIN          1..361
FT                   /note="Centromere kinetochore component CENP-T N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16171"
FT   DOMAIN          401..497
FT                   /note="CENP-T/Histone H4 histone fold"
FT                   /evidence="ECO:0000259|Pfam:PF15511"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          237..294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          365..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  55777 MW;  590018FA174A6E59 CRC64;
     MADRSILGEP TPRTLLRRVL DTADPRTPRR PRSARAGAQR ALLETPSSRR LRSQTKTTAR
     WNSRGARSSG RLAHAQASGH LEEQTPRTLL KNILLTAPES SILKPESVVK PVPAPQVVQP
     SRRESSRGSL ELQLPEPEPP TTLGPALLAP GRRKQRLRLS VFQQGVDQEL PVPQEPRGNA
     DASSLASSLN LTFATPLQPQ SVQRPGLARR PGTRRAVDVG AFLQDLRDTS LAPPNIVLED
     TQPFSQPLVD RSPSVRRSLP LPSHTAAEDT ERAASRRTRS SGSAPWNNSP GKPAQFLAGK
     AEEVNALALG FRNTSSSISG RGVEPLQDGV CEEAEKRMEE EASPELACNT PEFLQPKQLH
     QLLEPVPPPG PAVLSSEPLE PLSARLPPRP RATGPRPRQD PYKTGLSHYA KLFSFYAKMP
     MEKAALEIVE KCLDKYFRHL CDDLEAFATH AGRRTVKPED LELLMRRQGL VTDQVSLHVL
     VERHLPLEYR QLLIPCAFSG NSVFPAQ
//