ID A0A2K6EL87_PROCO Unreviewed; 415 AA.
AC A0A2K6EL87;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Zona pellucida-like domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040851};
DE AltName: Full=Cupulin {ECO:0000256|ARBA:ARBA00043069};
GN Name=ZPLD1 {ECO:0000313|Ensembl:ENSPCOP00000002495.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000002495.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000002495.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Glycoprotein which is a component of the gelatinous
CC extracellular matrix in the cupulae of the vestibular organ.
CC {ECO:0000256|ARBA:ARBA00037652}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004358}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004358}. Secreted, extracellular space,
CC extracellular matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_012508284.1; XM_012652830.1.
DR AlphaFoldDB; A0A2K6EL87; -.
DR STRING; 379532.ENSPCOP00000002495; -.
DR Ensembl; ENSPCOT00000008599.1; ENSPCOP00000002495.1; ENSPCOG00000007555.1.
DR GeneID; 105817198; -.
DR KEGG; pcoq:105817198; -.
DR CTD; 131368; -.
DR GeneTree; ENSGT00940000156527; -.
DR OMA; PFLMPVC; -.
DR OrthoDB; 5345199at2759; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR001507; ZP_dom.
DR PANTHER; PTHR14002; ENDOGLIN/TGF-BETA RECEPTOR TYPE III; 1.
DR PANTHER; PTHR14002:SF24; ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..415
FT /note="Zona pellucida-like domain-containing protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014323653"
FT TRANSMEM 373..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..320
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
FT REGION 319..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 45410 MW; 81CA0656DF85F711 CRC64;
MEQIWLLLLL TIRVLPGSAQ FNGYNCDANL HSRFPAERDI NVYCGVQTIT MKINFCTVLF
SGYSETDLAL NGRHGDSHCR GFINNNTFPA VVIFIINLST LEGCGNTLVV STIPGVSAYG
NATSVQIGNI SGYIDTPDPP TIISYLPGLL YKFSCSYPLE YLVNNTQLAS SSAAISVREN
NGTFVSTLNL LLYNDSTYNQ QLIIPSIGLP LKTKVFAAVQ ATNLDGRWNV LMDYCYTTPS
GNPNDDIRYD LFLSCDKDPQ TTVIENGRSQ RGRFSFEVFR FVKHKNQKMS TVFLHCVTKL
CRADDCPFLM PICGHRERRD AGRRTTGSPQ GTSGSAVLSA GPIITRSDET PTNNSQLGSP
NAPPFQLNAI TSALISGMVI LGVMSFSLLL CSLALLHRKG PTSLVLNGIR NPVFD
//
