ID A0A2K6EQ49_PROCO Unreviewed; 2693 AA.
AC A0A2K6EQ49;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=ITPR2 {ECO:0000313|Ensembl:ENSPCOP00000003856.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000003856.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000003856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR Ensembl; ENSPCOT00000013071.1; ENSPCOP00000003856.1; ENSPCOG00000011044.1.
DR GeneTree; ENSGT00940000156039; -.
DR OMA; PLETRAC; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF3; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044}; Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2222..2244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2256..2275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2296..2320
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2340..2368
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2389..2411
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2514..2537
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 112..166
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 231..287
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 324..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2624..2672
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2693 AA; 307162 MW; 4AAC9B304A2C9160 CRC64;
MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PEAGDLANPP KKFRDCLFKV
CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENKKL LGEIVKYSNV
IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIHPFWKLR SEGDNIVVGD
KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKI TLFMKYSSYR EDVLKGGDVV
RLFHAEQEKF LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEVEVVHHD PCRGGAGQWN
SLFRFKHLAT GNYLAAELNP DYRDAQNEGK NVRDGDLPTS KKKRQAGEKI MYTLVSVPHG
NDIASLFELD ATTLQRADCL VPRNSYVRLR HLCTNTWVTS TSIPIDTDEE RPVMLKIGTC
QTKEDKEAFA IVSVPLSEVR DLDFANDANK VLATTVKKLE NGTITQNERR FVTKLLEDLI
FFVADVPNNG QEVLDVVVTK PNRERQKLMR EQNILAQVFG ILKAPFKEKA GEGSMLRLED
LGDQRYAPYK YMLRLCYRVL RHSQQDYRKN QEYIAKNFCV MQSQIGYDIL AEDTITALLH
NNRKLLEKHI TAKEIETFVS LLRRNREPRF LDYLSDLCVS NTTAIPVTQE LICKFMLSPG
NADILIQTKV VSMQVDNPME SSMLPDDIDD EEVWLYWIDS NKEPHGKAIR HLAQEAKEGT
KADLEVLTYY RYQLNLFARM CLDRQYLAIN QISTQLSVDL ILRCVSDESL PFDLRASFCR
LMLHMHVDRD PQESVVPVRY ARLWTEIPTK ITIHEYDSIT DSSRNDMKRK FALTMEFVEE
YLKEVVNQPF PFGDKEKNKL TFEVVHLARN LIYFGFYSFS ELLRLTRTLL AILDIVQAPM
SSYFERLSKF QDGGNNVMRT IHGVGEMMTQ MVLSRGSIFP MSVPDVQPSI LPSKQGSPAE
HEDVTVMDTK LKIIEILQFI LSVRLDYRIS YMLSIYKKEF GEDSENTETS ANGSPDTLLP
SAIVPDIDEI AAQAETMFAG RKEKNPVQLD DEGGRTFLRV LIHLIMHDYP PLLSGALQLL
FKHFSQRAEV LQAFKQVQLL VSNQDVDNYK QIKADLDQLR LTVEKSELWV EKSSSYENGE
MGENQVKGGE ETLSPVFEGN RKPQIDSNKS NNYRIVKEIL IRLSKLCVQN KKCRNQHQRL
LKNMGAHSVV LDLLQIPYEK NDEKMNEVMN LAHTFLQNFC RGNPQNQVLL HKHLNLFLTP
GLLEAETMRH IFMNNYHLCN EISERVVQHF VHCIETHGRH VEYLRFLQTI VKADGKYVKK
CQDMVMTELI NGGEDVLIFY NDRASFPILL HMMCSERDRG DESGPLAYHI TLVELLAACT
EGKNVYTEIK CNSLLPLDDI VRVVTHDDCI PEVKIAYVNF VNHCYVDTEV EMKEIYTSNH
IWKLFENFLV DMARVCNTTT DRKHADIFLE KCVTESIMNI VSGFFNSPFS DNSTSLQTHQ
PVFIQLLQSA FRIYNCTWPN PAQKASVESC IRTLAEVAKN RGIAIPVDLD SQVNTLFMKS
HSNMVQRAAM GWRLSARSGP RFKEALGGPA WDYRNIIEKL QDVVASLEQQ FSPMMQAEFS
VLVDVLYSPE LLFPEGSDAR IRCGAFMSKL INHTKKLMEK EEKLCIKILQ TLREMLEKKD
SFMEEGNTLR KILLNRYFKG DYGVGMNGHL SGTYSKTAQV GGSFSGQDSD KMGISMSDIQ
CLLDKEGASE LVIDVIVNTK NDRIFSEGIF LGIALLEGGN TQTQYSFYQQ LHEQKKSEKF
FKVLYDRMKA AQKEIRSTVT VNTIDLGSKK RDDDSELMTS GPRMRVRDSS LHLKEGMKGQ
LTEASSATSK AYCVYRREMD PEIDIMCTGP EAGNAEDKSA EEVTMSPAIA IMQPILRFLQ
LLCENHNREL QNFLRNQNNK TNYNLVCETL QFLDCICGST TGGLGLLGLY INEKNVALVN
QTLESLTEYC QGPCHENQTC IATHESNGID IIIALILNDI NPLGKYRMDL VLQLKNNASK
LLLAIMESRH DSENAERILF NMRPRELVDV MKNAYNQGLE CDHGDDEGGD DGVSPKDVGH
NIYILAHQLA RHNKLLQQML KPGSDPDEGD EALKYYANHT AQIEIVRHDR TMEQIVFPVP
NICEYLTRES KCRVFNTTER DEQGSKVNDF FQQTEDLYNE MKWQKKIRNN PALFWFSRHI
SLWGSISFNL AVFINLAVAL FYPFGDDGDE GTLSPLFSVL LWIAVAICTS MLFFFSKPVG
IRPFLVSVML RSIYTIGLGP TLILLGAANL CNKIVFLVSF VGNRGTFTRG YRAVILDVAF
LYHVAYVLVC MLGLFVHEFF YSFLLFDLVY REETLVNVIK SVTRNGRSII LTAVLALILV
YLFSIIGFLF LKDDFTMEVD RLKNRTPVTG SHQVPTLTTI MGTCTKENCS PTIPASNTAE
EEYEDGIERT CDTLLMCIVT VLNQGLRNGG GVGDVLRRPS KDEPLFAARV VYDLLFYFIV
IIIVLNLIFG VIIDTFADLR SEKQKKEEIL KTTCFICGLE RDKFDNKTVS FEEHIKSEHN
MWHYLYFIVL VKVKDPTEYT GPESYVAQMI VEKNLDWFPR MRAMSLVSNE GDSEQNEIRN
LQEKLESTMS LVKQLSGQLA ELKEQMTEQR KNKQRLGFLG SNTPHVNHHM PPH
//
