ID A0A2K6EQA9_PROCO Unreviewed; 842 AA.
AC A0A2K6EQA9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Short transient receptor potential channel 1 {ECO:0000256|ARBA:ARBA00013302};
GN Name=TRPC1 {ECO:0000313|Ensembl:ENSPCOP00000003919.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000003919.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000003919.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC permeant cation channel. Probably is operated by a phosphatidylinositol
CC second messenger system activated by receptor tyrosine kinases or G-
CC protein coupled receptors. Seems to be also activated by intracellular
CC calcium store depletion. {ECO:0000256|ARBA:ARBA00003698}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. TRPC1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009944}.
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DR AlphaFoldDB; A0A2K6EQA9; -.
DR STRING; 379532.ENSPCOP00000003919; -.
DR Ensembl; ENSPCOT00000013302.1; ENSPCOP00000003919.1; ENSPCOG00000011684.1.
DR GeneTree; ENSGT01060000248594; -.
DR OMA; SRPTIVX; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:Ensembl.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005457; TRPC1_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF56; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01642; TRPCHANNEL1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..486
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..525
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 545..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 669..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 242..304
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 95719 MW; 242E1251515ABA33 CRC64;
MPFGANGPHA EAAVGTTHPF SSPGAGLGSG SGPVGAPPLS PGLPASWAAM MAALYPSTDL
SGASSSSLPS SPSSSSPNEV MALKDVREVK EENTLNEKLF LLACDKGDYY MVKKILEENS
SGDLNINCVD VLGRNAVTIT IENENLDILQ LLLDYGCQSA DALLVAIDSE VVGAVDILLN
HRTKRSSRPT IVKLMERIQN PEYSTTMDVA PVILAAHRNN YEILTMLLKQ DVSLPKPHAV
GCECTLCSAK NKKDSLRHSR FRLDIYRCLA SPALIMLTEE DPILRAFELS ADLKELSLVE
VEFRNDYEEL ARQCKMFAKD LLAQARNSRE LEVILNHTSN DEPLDKRGLL EERMNLSRLK
LAIKYNQKEF VSQSNCQQFL NTVWFGQMSG YRRKPTCKKI MTVLTVGIFW PVLSLCYLIA
PKSQFGRIIH TPFMKFIIHG ASYFTFLLLL NLYSLVYNED KKNTMGPALE RIDYLLILWI
IGMIWSDIKR LWYEGLEDFL EESRNQLSFV MNSLYLATFA LKVVAHNKFH DFADRKDWDA
FHPTLVAEGL FAFANVLSYL RLFFMYTTSS VLGPLQISMG QMLQDFGKFL GMFLLVLFSF
TIGLTQLYDK GYTPKEQKDC VGIFCEQQSN DTFHSFIGTC FALFWYIFSL AHVAIFVTRF
SYGEELQSFV GAVIVGTYNV VVVIVLTKLL VAMLHKSFQL IANHEDKEWK FARAKLWLSY
FEDKCTLPPP FNIIPSPKTI CYMISSLSKW ICSHTSKGKV KRQNSLKEWR NLKQKRDENY
QKVMCCLVHR YLTSMRQKMQ STDQATVENL NELRQDLSKF RNEIRDLLGF RTSKYAMFYS
RN
//
