ID   A0A2K6ER18_PROCO        Unreviewed;       480 AA.
AC   A0A2K6ER18;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Interleukin 18 receptor accessory protein {ECO:0000313|Ensembl:ENSPCOP00000004179.1};
GN   Name=IL18RAP {ECO:0000313|Ensembl:ENSPCOP00000004179.1};
OS   Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS   coquereli).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC   Indriidae; Propithecus.
OX   NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000004179.1, ECO:0000313|Proteomes:UP000233160};
RN   [1] {ECO:0000313|Ensembl:ENSPCOP00000004179.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009752}.
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DR   AlphaFoldDB; A0A2K6ER18; -.
DR   STRING; 379532.ENSPCOP00000004179; -.
DR   Ensembl; ENSPCOT00000014027.1; ENSPCOP00000004179.1; ENSPCOG00000012338.1.
DR   GeneTree; ENSGT01090000259985; -.
DR   OMA; EPQKSHF; -.
DR   Proteomes; UP000233160; Unplaced.
DR   GO; GO:0045092; C:interleukin-18 receptor complex; IEA:Ensembl.
DR   GO; GO:0015026; F:coreceptor activity; IEA:Ensembl.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042008; F:interleukin-18 receptor activity; IEA:Ensembl.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0042119; P:neutrophil activation; IEA:Ensembl.
DR   GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11890:SF23; INTERLEUKIN-18 RECEPTOR ACCESSORY PROTEIN; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233160};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        217..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          16..97
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          109..211
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          264..417
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          443..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..480
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   480 AA;  54494 MW;  445920FF0F9EA0CD CRC64;
     MVLEVKLQTN ASCENPTLHK QYLLLGSTNS IHCPSLSCQS GVQSPEVTWY QNGKRLSEQR
     SDPMVVDEVY DFHQGTYICD YTQSDNASSW TVRAVVQVRT IVEDTNLKPD ILDPIKDTLE
     VELGKPLTIS CRARFGFERV FKPVIRWYIK DSDREWEVSV PEAKSIKSTL KDEVIERDVI
     LEEVTRSDLH RKFVCFAQNS IGNTTQSIQL KEKKGVLFLY LLLGTVVTLV GVLAASALLY
     RHWIEIVLLY RTYQSKDETL GDKKEFDAFV SYAKWSSFES EAASSLSEEH LALNLFPEVL
     ENKYGYTLCL LERDVAPGGV YTEDIVSIIK KSRRGIFILS PNYVNGPSVF ELQAAVNLAL
     ADQTLKLILI KFCCFQEPAS LPHLVKKALR VLPTVTWRGL KSVPPSSRFW TEMRYHMPVK
     NSKGFTWNHL RIIPGVSHWK RLSKTETTGR SSQPSEQWSH LPSSPRDRDT AGQNTQHGSG
//