ID A0A2K6ER64_PROCO Unreviewed; 1243 AA.
AC A0A2K6ER64;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Euchromatic histone lysine methyltransferase 2 {ECO:0000313|Ensembl:ENSPCOP00000004215.1};
GN Name=EHMT2 {ECO:0000313|Ensembl:ENSPCOP00000004215.1};
OS Propithecus coquereli (Coquerel's sifaka) (Propithecus verreauxi
OS coquereli).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes;
OC Indriidae; Propithecus.
OX NCBI_TaxID=379532 {ECO:0000313|Ensembl:ENSPCOP00000004215.1, ECO:0000313|Proteomes:UP000233160};
RN [1] {ECO:0000313|Ensembl:ENSPCOP00000004215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K6ER64; -.
DR Ensembl; ENSPCOT00000014117.1; ENSPCOP00000004215.1; ENSPCOG00000012310.1.
DR GeneTree; ENSGT00940000159459; -.
DR Proteomes; UP000233160; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000233160}.
FT REPEAT 717..749
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 750..782
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 783..807
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 817..849
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 883..915
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1005..1068
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 1071..1188
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..384
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1243 AA; 135575 MW; 6563FC09D604C46D CRC64;
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA SWAPQLPTGL
TSPPVPCRPS QGEAPAEMGA LLLEKETRGA PERVHGSLGD NPHSEETLPK ANPDSLEPTG
PSSPASVTVT VGDEGADTPV GAIPLIGDEP GTLEGDGDLH GGRILLGHAT KSFPSSPSKG
GACPSRAKMS MTGAGKSPPS VQSLAMRLLS MPGAQGTASA GPEPPPATSS PEGQPKVHRA
RKTMSKPGNG QPPVPEKRPP EVQHFRMSDD VHSLGKVTAD VAKRRKLNSG AGLSEELGSA
RGSEVTVQKG NPGPLEEWET VVGDDFSLYY DSYSVDERVD SDSKSEVEAL AEQLSEEEEE
EEEEEEEEEE EEEEEEEEEE DEESGNQSDR VRVARTLTLS VSVSGVNGVG SSGPSEYMEV
PLGSLELPSE GTLSPNHAGV SNDTSSLETE RGFEELPLCS CRMEAPKIDR ISERAGHKCM
ATESVDGELL GCNAAILKRE TMRPSSRVAL MVLCETHRAR MVKHHCCPGC GYFCTAGTFL
ECHPDFRVAH RFHKACVSQL NGMVFCPHCG EDASEAQEVT IPRGDGVTPP AGTAAPAPPP
LAQDAPGRAD TSQPSARMRG HGEPRRPPCD PLTDTIDSSG PSLTLPNGGC LSAVGLPLGP
GREALEKALV IQESERRKKL RFHPRQLYLS VKQGELQKVI LMLLDNLDPN FQSDQQSKRT
PLHAAAQKGS VEICHVLLQA GANINAVDKQ QRTPLMEAVV NNHLEVARYM VQRGGCVYSK
EEDGSTCLHH AAKIGNLEMV SLLLGTGQVD VNAQDSGGWT PIIWAAEHKH IEVIRMLLTR
GADVTLTDNE ENICLHWASF TGSAAIAEVL LNARCDLHAV NYHGDTPLHI AARESYHDCV
LLFLSRGANP ELRNKEGDTA WDLTPERSDV WFALQLNRKL RLGVGNRAIR TEKIICRDVA
RGYENVPIPC VNGVDGEPCP EDYKYISENC ETSTMNIDRN ITHLQHCTCV DDCSSSNCLC
GQLSIRCWYD KDGRLLQEFN KIEPPLIFEC NQACSCWRNC KNRVVQSGIK VRLQLYRTAK
MGWGVRALQT IPQGTFICEY VGELISDAEA DVREDDSYLF DLDNKDGEVY CIDARYYGNI
SRFINHLCDP NIIPVRVFML HQDLRFPRIA FFSSRDIRTG EELGFDYGDR FWDIKSKYFT
CQCGSEKCKH SAEAIALEQS RLARLDPHPE LLPELGSLPP VNT
//
